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Year Source Title
2015 NIHR Horizon Scanning Centre (NIHR HSC) Simeprevir in combination with sofosbuvir (with or without ribavirin) for chronic hepatitis C
2015 NIHR Horizon Scanning Centre (NIHR HSC) Sarilumab for moderate to severe active rheumatoid arthritis
2015 NIHR Horizon Scanning Centre (NIHR HSC) Tofacitinib for chronic plaque psoriasis – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Cx601 (Alofisel®) for complex perianal fistula in adults with non-active or mildly-active luminal Crohn's disease – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Tildrakizumab for moderate to severe plaque psoriasis
2015 NIHR Horizon Scanning Centre (NIHR HSC) Natalizumab (Tysabri) for secondary progressive multiple sclerosis
2015 NIHR Horizon Scanning Centre (NIHR HSC) Clostridium botulinum neurotoxin type A (Xeomin) for sialorrhoea associated with adult Parkinson's disease and paediatric cerebral palsy
2015 NIHR Horizon Scanning Centre (NIHR HSC) Ticagrelor (Brilique) for preventing thombotic events in patients with acute ischaemic stroke or high risk transient ischaemic attack
2015 NIHR Horizon Scanning Centre (NIHR HSC) APN311 for high risk neuroblastoma in children and adolescents – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Atezolizumab for urothelial bladder cancer – second and subsequent line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Brentuximab vedotin (Adcetris) for CD30-positive cutaneous T-cell lymphoma
2015 NIHR Horizon Scanning Centre (NIHR HSC) Buparlisib in combination with fulvestrant for hormone-receptor positive/HER2-negative locally advanced or metastatic breast cancer
2015 NIHR Horizon Scanning Centre (NIHR HSC) Cabozantinib (Cometriq) for metastatic renal cell carcinoma –second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Elotuzumab with lenalidomide for multiple myeloma – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Neratinib with capecitabine for advanced or metastatic HER2-positive breast cancer – third line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Palbociclib for advanced or metastatic, oestrogen-receptor positive, HER2-negative, recurrent breast cancer – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Vandetanib (Caprelsa) for locally advanced or metastatic differentiated thyroid cancer – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Vemurafenib (Zelboraf) for metastatic BRAF V600 mutation positive melanoma in children and adolescents
2015 NIHR Horizon Scanning Centre (NIHR HSC) GS-6615 for long QT-3 syndrome
2015 NIHR Horizon Scanning Centre (NIHR HSC) Holoclar for the treatment of limbal stem cell deficiency due to ocular burns
2015 NIHR Horizon Scanning Centre (NIHR HSC) Midodrine (Bramox) for orthostatic hypotension
2015 NIHR Horizon Scanning Centre (NIHR HSC) Tenofovir alafenamide monotherapy for hepatitis B
2015 NIHR Horizon Scanning Centre (NIHR HSC) Baricitinib for moderate to severe rheumatoid arthritis
2015 NIHR Horizon Scanning Centre (NIHR HSC) Certolizumab (Cimzia) for early rheumatoid arthritis – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Tofacitinib for psoriatic arthritis – second or subsequent line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Patiromer for hyperkalaemia – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Alectinib for advanced ALK-positive, non-small cell lung cancer – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Alectinib for locally advanced or metastatic ALK-positive, non-small cell lung cancer following failure of crizotinib
2015 NIHR Horizon Scanning Centre (NIHR HSC) Atezolizumab for locally advanced or metastatic non-small cell lung cancer – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Bavituximab for advanced non-small cell lung cancer – second line in combination with docetaxel
2015 NIHR Horizon Scanning Centre (NIHR HSC) Bevacizumab (Avastin) with erlotinib (Tarceva) for EGFR positive, advanced or metastatic non-small cell lung cancer – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Dabrafenib (Tafinlar) and trametinib (Mekinist) combination therapy for metastatic BRAF V600E positive non-small cell lung cancer
2015 NIHR Horizon Scanning Centre (NIHR HSC) Daratumumab monotherapy for relapsed and refractory multiple myeloma
2015 NIHR Horizon Scanning Centre (NIHR HSC) Daratumumab with lenalidomide and dexamethasone for relapsed or refractory multiple myeloma
2015 NIHR Horizon Scanning Centre (NIHR HSC) Gemtuzumab ozogamicin (Mylotarg) with conventional chemotherapy for acute myeloid leukaemia – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) MABp1 (Xilonix) for metastatic colorectal cancer –third line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Obinutuzumab (Gazyvaro) for indolent non-Hodgkin lymphoma – first line, in combination with chemotherapy
2015 NIHR Horizon Scanning Centre (NIHR HSC) Pelareorep (Reolysin) with or without chemotherapy for metastatic malignant melanoma – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Pelareorep (Reolysin) in combination with chemotherapy for metastatic or recurrent squamous cell carcinoma of the head and neck – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Pembrolizumab (Keytruda) for PD-L1 strong-positive metastatic non-small cell lung cancer – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Glycerol phenylbutyrate (Ravicti) for urea cycle disorders (hyperammonaemia)
2015 NIHR Horizon Scanning Centre (NIHR HSC) GSK2696273 for severe combined immunodeficiency due to adenosine deaminase deficiency
2015 NIHR Horizon Scanning Centre (NIHR HSC) Lopixibat for progressive familial intrahepatic cholestasis in paediatric patients
2015 NIHR Horizon Scanning Centre (NIHR HSC) Masitinib for Crohn's disease, in patients intolerant or with an unsatisfactory response to immunosuppressive drugs and/or TNF-inhibitors
2015 NIHR Horizon Scanning Centre (NIHR HSC) Masitinib for primary and relapse-free secondary progressive multiple sclerosis – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Masitinib for rheumatoid arthritis – second and subsequent line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Sirukumab for rheumatoid arthritis
2015 NIHR Horizon Scanning Centre (NIHR HSC) Tadalafil (Cialis) for Duchenne muscular dystrophy
2015 NIHR Horizon Scanning Centre (NIHR HSC) Ataluren (Translarna) for CFTR class I nonsense mutation mediated cystic fibrosis
2015 NIHR Horizon Scanning Centre (NIHR HSC) Benralizumab for uncontrolled asthma – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Abiraterone (Zytiga) for hormone-naïve metastatic prostate cancer – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Bevacizumab (Avastin) with lomustine for glioblastoma – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Dacomitinib for locally advanced or metastatic EGFR positive non-small cell lung cancer – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Fulvestrant (Faslodex) for advanced or metastatic, hormone-receptor positive breast cancer – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Idelalisib (Zydelig) with bendamustine and rituximab for chronic lymphocytic leukaemia – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Nivolumab (Opdivo) for diffuse large B cell lymphoma –second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Nivolumab for recurrent glioblastoma – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Nivolumab (Opdivo) for Hodgkin lymphoma in brentuximab treated patients – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Nivolumab (Opdivo) for Hodgkin lymphoma in brentuximab naïve patients – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Nivolumab (Opdivo) for recurrent or metastatic squamous cell carcinoma of the head and neck – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Olaratumab with doxorubicin for advanced soft tissue sarcoma
2015 NIHR Horizon Scanning Centre (NIHR HSC) Pembrolizumab (Keytruda) for advanced or metastatic urothelial cancer – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Plitidepsin (Aplidin) for relapsed and refractory multiple myeloma – fourth line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Regorafenib (Stivarga) for hepatocellular carcinoma – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Ribociclib for advanced hormone receptor positive, HER2 negative breast cancer – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Selumetinib for KRAS mutation-positive advanced non-small cell lung cancer – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Talazoparib for locally advanced and/or metastatic breast cancer with germline BRCA 1/2 positive mutation
2015 NIHR Horizon Scanning Centre (NIHR HSC) Venetoclax for chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
2015 NIHR Horizon Scanning Centre (NIHR HSC) Vincristine liposomal (Marqibo) for relapsed or refractory acute lymphoblastic leukaemia – third line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Vincristine liposomal (Marqibo) in combination with chemotherapy for elderly patients with newly diagnosed CD20 positive diffuse large B-cell lymphoma – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Eprodisate disodium (Kiacta) for AA amyloidosis
2015 NIHR Horizon Scanning Centre (NIHR HSC) STG 320 for allergic rhinitis
2015 NIHR Horizon Scanning Centre (NIHR HSC) Cerliponase alfa for neuronal ceroid lipofuscinosis type 2 (CLN2 disease)
2015 NIHR Horizon Scanning Centre (NIHR HSC) Pridopidine (Huntexil) for Huntington's disease
2015 NIHR Horizon Scanning Centre (NIHR HSC) Aflibercept solution (Eylea) for visual impairment due to choroidal neovascularisation secondary to pathological myopia
2015 NIHR Horizon Scanning Centre (NIHR HSC) rhNGF for neurotrophic keratitis – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Abatacept for psoriatic arthritis – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Bimagrumab for sporadic inclusion body myositis – first line
2015 NIHR Horizon Scanning Centre (NIHR HSC) Remestemcel-L (Prochymal) for steroid refractory acute graft versus host disease – second line
2015 NIHR Horizon Scanning Centre (NIHR HSC) XEN Gel Stent for glaucoma treatment
2015 NIHR Horizon Scanning Centre (NIHR HSC) Permaseal for soft tissue access and closure during procedures
2015 NIHR Horizon Scanning Centre (NIHR HSC) ENROUTE transcarotid neuroprotection and stent systems
2015 NIHR Horizon Scanning Centre (NIHR HSC) AventaMed device for tympanostomy tube placement
2015 NIHR Horizon Scanning Centre (NIHR HSC) Ostom-I Alert Sensor for use with ostomy bags
2015 NIHR Horizon Scanning Centre (NIHR HSC) Hand-held Fourier transform infrared (FTIR) spectroscopy to diagnose and monitor COPD
2015 NIHR Horizon Scanning Centre (NIHR HSC) Arsenal ResQFoam™ for non-compressible abdominal haemorrhage
2015 NIHR Horizon Scanning Centre (NIHR HSC) XStat® Hemostatic Device for non-compressible junctional haemorrhage
2015 NIHR Horizon Scanning Centre (NIHR HSC) Nitric Oxide generating gel dressing for diabetic foot ulcers
2015 NIHR Horizon Scanning Centre (NIHR HSC) Freedom Spinal Cord Stimulator System for chronic back and leg pain
2015 NIHR Horizon Scanning Centre (NIHR HSC) Inreda artificial pancreas device for Type 1 diabetes
2015 NIHR Horizon Scanning Centre (NIHR HSC) Rapid Rhythm ECG for atrial fibrillation
2015 NIHR Horizon Scanning Centre (NIHR HSC) Noctura 400 Sleep Mask for diabetic retinopathy
2015 NIHR Horizon Scanning Centre (NIHR HSC) OnPulse™ nerve stimulation technology for urinary and faecal incontinence
2015 NIHR Horizon Scanning Centre (NIHR HSC) Fall-Safe Assist device for the prevention and detection of falls
2015 NIHR Horizon Scanning Centre (NIHR HSC) Reza Band® for laryngopharyngeal reflux
2015 NIHR Horizon Scanning Centre (NIHR HSC) Sonata™ System for the removal of uterine fibroids
2015 NIHR Horizon Scanning Centre (NIHR HSC) Lithoplasty® balloon catheter for peripheral arterial disease
2015 NIHR Horizon Scanning Centre (NIHR HSC) Serenity System® to treat tinnitus
2015 NIHR Horizon Scanning Centre (NIHR HSC) MolecuLight i:X for visualisation of bacteria in chronic wounds
2015 NIHR Horizon Scanning Centre (NIHR HSC) BuddyWOTCH™ to monitor COPD