Holoclar for the treatment of limbal stem cell deficiency due to ocular burns
NIHR HSRIC
Record ID 32016000362
English
Authors' objectives:
Holoclar is a preparation of ex vivo expanded autologous human corneal epithelial cells containing stem cells. It is intended for use in adults with moderate to severe limbal stem cell deficiency (LSCD) caused by physical or chemical ocular burns.
In the EU, an estimated 0.3 in 10,000 people are affected by LSCD due to ocular burns, which is equivalent to about 15,000 people, however, expert opinion suggests this may be an overestimation for the UK.
The ultimate aim of treatments for LSCD is to restore a healthy conjunctival and corneal surface. Treatments for partial LSCD include topical steroids, ocular lubricants, bandage contact lenses and autologous serum. With increased corneal conjuctivalisation, repeated scraping of the conjunctivalised epithelium in the presence of some remaining corneal stem cell tissue may be performed. Amniotic membrane transplantation with sutures or fibrin glue as an adjunctive treatment may also be performed. More extensive LSCD may require conjunctival and keratolimbal allografts, possibly followed by corneal grafts. In patients with unilateral LSCD, the use of limbal stem cells from the unaffected eye may be enhanced by tissue culture prior to grafting. There is currently no specifically approved treatment available for corneal lesions with associated LSCD caused by ocular burns.
Holoclar has been granted a conditional Marketing Authorisation for use in the EU for this indication.
Details
Project Status:
Completed
Year Published:
2015
URL for published report:
http://www.hsric.nihr.ac.uk/topics/holoclar-for-the-treatment-of-limbal-stem-cell-deficiency-due-to-ocular-burns/
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Humans
- Burns
- Corneal Diseases
- Eye
- Stem Cells
Contact
Organisation Name:
NIHR Horizon Scanning Centre
Contact Address:
The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health and Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom. Tel: +44 121 414 7831, Fax: +44 121 2269
Contact Name:
c.packer@bham.ac.uk
Contact Email:
c.packer@bham.ac.uk
Copyright:
NIHR Horizon Scanning Research&Intelligence Centre (NIHR HSRIC)
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