Authors' objectives: Diffuse large B-cell lymphoma is a cancer of white blood cells called lymphocytes that normally help the body to fight infections. Lymphoma is more common among older people. Treating older patients who often have other additional medical conditions can be a difficult task. Many of the drugs currently used for the treatment of lymphoma can have serious side effects. Vincristine liposomal is a new form of a chemotherapy drug called vincristine that may be more effective and less toxic than current chemotherapy because it is encapsulated in a protective shell. It is delivered straight into the bloodstream via a drip. Some studies have suggested vincristine liposomal may be helpful for elderly people who have had no previous treatment for lymphoma and more studies are now aiming to show how well it works and whether it is safe to use. If vincristine liposomal is licenced for use in the UK, it could be a new treatment option for newly diagnosed elderly patients with diffuse large B-cell lymphoma. It may improve survival and quality of life as it may cause fewer side effects than current treatments.

Project Status: Completed

Year Published: 2015

URL for published report: http://www.hsric.nihr.ac.uk/topics/vincristine-liposomal-marqibo-in-combination-with-chemotherapy-for-elderly-patients-with-newly-diagnosed-cd20-positive-diffuse-large-b-cell-lymphoma-first-line/

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: England, United Kingdom

Organisation Name: NIHR Horizon Scanning Centre

Contact Address: The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health and Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom. Tel: +44 121 414 7831, Fax: +44 121 2269

Contact Name: c.packer@bham.ac.uk

Contact Email: c.packer@bham.ac.uk

Copyright: NIHR Horizon Scanning Research&Intelligence Centre (NIHR HSRIC)