• Search History (Register)
  • MeSH Browser
    • Afrikaans
      Albanian
      Arabic
      Armenian
      Basque
      Bengali
      Bulgarian
      Catalan
      Cambodian
      Chinese (Mandarin)
      Chinese (Cantonese)
      Croatian
      Czech
      Danish
      Dutch
      English
      Estonian
      Fiji
      Finnish
      French
      Georgian
      German
      Greek
      Gujarati
      Hebrew
      Hindi
      Hungarian
      Icelandic
      Indonesian
      Irish
      Italian
      Japanese
      Javanese
      Korean
      Latin
      Latvian
      Lithuanian
      Macedonian
      Malay
      Malayalam
      Maltese
      Maori
      Marathi
      Mongolian
      Nepali
      Norwegian
      Persian
      Polish
      Portuguese
      Punjabi
      Quechua
      Romanian
      Russian
      Samoan
      Serbian
      Slovak
      Slovenian
      Spanish
      Swahili
      Swedish
      Tamil
      Tatar
      Telugu
      Thai
      Tibetan
      Tonga
      Turkish
      Ukrainian
      Urdu
      Uzbek
      Vietnamese
      Welsh
      Xhosa
      Apply
    • Adelaide Health Technology Assessment
      Agence d'évaluation des technologies et des modes d'intervention en santé
      Agencia de Evaluacion de Tecnologias Sanitarias
      Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS)
      Agencia de Qualitat i Avaluacio Sanitries de Catalunya
      Agency for Care Effectiveness (ACE)
      Agency for Health Technology Assessment and Tariff System
      Agency for Healthcare Research and Quality
      Agenzia Sanitaria e Sociale Regionale (Regional Agency for Health and Social Care)
      All Wales Medicines Strategy Group
      Andalusian Health Technology Assessment Area
      Australian Health Technology Advisory Committee
      Australian Safety and Efficacy Register of New Interventional Procedures-Surgical
      Austrian Institute for Health Technology Assessment
      Basque Office for Health Technology Assessment
      Belgian Health Care Knowledge Centre
      BlueCross BlueShield Association
      British Columbia Office of Health Technology Assessment
      Canadian Agency for Drugs and Technologies in Health
      Canadian Coordinating Office for Health Technology Assessment
      Canadian Task Force on Preventive Health Care
      Canary Health Service
      Cellule Innovation of the AP-HP
      Center for Drug Evaluation
      Center for Medical Technology Assessment
      Center for Outcomes Research and Economic Evaluation for Health
      Centre for Clinical Effectiveness
      Centre for Reviews and Dissemination
      Centre for Technology Assessment at the Swiss Science and Technology Council
      Centre Hospitalier de l'Universite de Montreal
      Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale
      Committee for New Health Technology Assessment
      Conseil d'Evaluation des Technologies de la Santé du Québec
      Coordenação-Geral de Fomento à Pesquisa e Avaliação de Tecnologias em Saúde, Departamento de Ciência e Tecnologia
      Danish Centre for Evaluation and Health Technology Assessment
      Danish Institute for Health Services Research
      ECRI Institute
      European Network for Health Technology Assessment
      Finnish Coordinating Center for Health Technology Assessment
      Finnish Coordinating Center for Health Technology Assessment
      Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore
      German Agency for HTA at the German Institute for Medical Documentation and Information
      Gesundheit Osterreich GmbH
      Hannover Medical School, Medizinische Hochschule Hannover
      Haute Autorité de Santé
      HAYES, Inc.
      Health Council of the Netherlands Gezondheidsraad
      Health Information and Quality Authority (HIQA)
      Health Intervention and Technology Assessment Program
      Health Quality Ontario
      Health Sciences Institute in Aragon (IACS)
      Health Services Assessment Collaboration
      Health Services Utilization and Research Commission
      Health Technology Advisory Committee
      Health Technology and Policy Unit
      Health Technology Assessment Section, Ministry of Health Malaysia
      Health Technology Board for Scotland
      Health Technology Reference Group
      Health Technology Wales
      HTA Region Stockholm
      HTA South
      HTA Unit, University of Calgary
      Institut national d'excellence en sante et en services sociaux
      Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval (IUCPQ-ULaval)
      Institute for Clinical and Economic Review
      Institute for Clinical Effectiveness and Health Policy
      Institute for Clinical Evaluative Sciences
      Institute for Clinical Systems Improvement
      Institute for Quality and Efficiency in Health Care (IQWiG)
      Institute of Applied Health Sciences
      Institute of Health Economics
      Institute of Health Economics
      Institute of Health Technology Assessment and Research (IETSI)
      Institute of Technology Assessment
      Israel Center for Technology Assessment in Health Care
      L'Agence Nationale d'Accreditation d'Evaluation en Santé
      Ludwig Boltzmann Institute for Health Technology Assessment
      Malaysian Health Technology Assessment
      Malaysian Health Technology Assessment Unit
      Medical Advisory Secretariat
      Medical Services Advisory Committee
      Monash Business School, Monash University (MBS)
      National Authority for Assessment and Accreditation in Healthcare (INEAS)
      National Committee for Technology Incorporation (CONITEC)
      National Evidence-based healthcare Collaborating Agency
      National Institute for Clinical Excellence
      National Institute for Health and Care Excellence
      New Zealand Health Technology Assessment
      New Zealand National Health Committee
      NIHR Health and Social Care Delivery Program
      NIHR Health Services and Delivery Research programme
      NIHR Health Technology Assessment programme
      NIHR Horizon Scanning Centre
      NIHR Public Health Research programme
      Norwegian Institute of Public Health
      Norwegian Institute of Public Health
      Norwegian Medical Products Agency
      Ontario Health
      Penn Medicine Center for Evidence-based Practice
      Quality Improvement Scotland
      Scientific Advice Unit, avalia-t; The Galician Health Knowledge Agency (ACIS)
      Scottish Health Purchasing Information Centre
      Scottish Health Technologies Group
      Scottish Medicines Consortium (SMC)
      State Health Care Accreditation Agency under the Ministry of Health of the Republic of Lithuania
      Swedish Agency for Health Technology Assessment and Assessment of Social Services
      Swedish Agency for Health Technology Assessment and Assessment of Social Services
      Swiss Federal Office of Public Health (FOPH)
      Technology Assessment at SickKids
      Technology Assessment Unit of the McGill University Health Centre (MUHC)
      The Danish Health Technology Council
      The Federal Joint Committee
      The HTA Center of the Stockholm County Council/Gotland
      The Italian National Agency for Regional Health Services (Agenas)
      The National Health Care Institute (ZIN, Zorginstituut Nederland)
      The National Health Care Institute (Zorginstituut Nederland)
      The Netherlands Organisation for Health Research and Development
      The Regional Health Technology Assessment Centre
      TNO
      U. S. Congress. Office of Technology Assessment
      Unidad de Evaluacion de Tecnologias Sanitarias
      Unidad de Tecnologias de Salud
      Unit of Health Economics and Technology Assessment in Health Care
      University HealthSystem Consortium
      University of York
      VA Technology Assessment Program
      Washington Singer Press
      Washington State Department of Labor and Industries (WSDLI)
      Wessex Institute for Health Research and Development
      West Midlands Health Technology Assessment Collaboration
      WorkSafeBC
      Apply
    • Afghanistan
      Albania
      Algeria
      Andorra
      Antigua and Barbuda
      Argentina
      Armenia
      Australia
      Austria
      Azerbaijan
      Bahamas
      Bahrain
      Bangladesh
      Barbados
      Belarus
      Belgium
      Belize
      Benin
      Bhutan
      Bolivia
      Bosnia and Herzegovina
      Botswana
      Brazil
      Brunei
      Bulgaria
      Burkina Faso
      Burundi
      Cambodia
      Cameroon
      Canada
      Cape Verde
      Central African Republic
      Chad
      Chile
      China
      Colombia
      Comoros
      Congo
      Costa Rica
      Cote dIvoire
      Croatia
      Cuba
      Cyprus
      Czech Republic
      Denmark
      Djibouti
      Dominica
      Dominican Republic
      East Timor
      Ecuador
      Egypt
      El Salvador
      Equatorial Guinea
      Eritrea
      Estonia
      Ethiopia
      Fiji
      Finland
      France
      Gabon
      Gambia
      Georgia
      Germany
      Ghana
      Greece
      Grenada
      Guatemala
      Guinea
      Guinea-Bissau
      Guyana
      Haiti
      Honduras
      Hong Kong
      Hungary
      Iceland
      India
      Indonesia
      Iran
      Iraq
      Ireland
      Israel
      Italy
      Jamaica
      Japan
      Jordan
      Kazakhstan
      Kenya
      Kiribati
      North Korea
      South Korea
      Kuwait
      Kyrgyzstan
      Laos
      Latvia
      Lebanon
      Lesotho
      Liberia
      Libya
      Liechtenstein
      Lithuania
      Luxembourg
      Macedonia
      Madagascar
      Malawi
      Malaysia
      Maldives
      Mali
      Malta
      Marshall Islands
      Mauritania
      Mauritius
      Mexico
      Micronesia
      Moldova
      Monaco
      Mongolia
      Montenegro
      Morocco
      Mozambique
      Myanmar
      Namibia
      Nauru
      Nepal
      Netherlands
      New Zealand
      Nicaragua
      Niger
      Nigeria
      Norway
      Oman
      Pakistan
      Palau
      Panama
      Papua New Guinea
      Paraguay
      Peru
      Philippines
      Poland
      Portugal
      Puerto Rico
      Qatar
      Romania
      Russia
      Rwanda
      Saint Kitts and Nevis
      Saint Lucia
      Saint Vincent and the Grenadines
      Samoa
      San Marino
      Sao Tome and Principe
      Saudi Arabia
      Senegal
      Serbia and Montenegro
      Seychelles
      Sierra Leone
      Singapore
      Slovakia
      Slovenia
      Solomon Islands
      Somalia
      South Africa
      Spain
      Sri Lanka
      Sudan
      Suriname
      Swaziland
      Sweden
      Switzerland
      Syria
      Taiwan
      Tajikistan
      Tanzania
      Thailand
      Togo
      Tonga
      Trinidad and Tobago
      Tunisia
      Turkey
      Turkmenistan
      Tuvalu
      Uganda
      Ukraine
      United Arab Emirates
      United Kingdom
      United States
      Uruguay
      Uzbekistan
      Vanuatu
      Vatican City
      Venezuela
      Vietnam
      Yemen
      Zambia
      Zimbabwe
      Apply

Welcome to the international HTA database

CSV RIS
Showing [24125 Records] Selected Records [0 Hits] [Clear]
Year Source Title
2004     Malaysian Health Technology Assessment Unit (MHTAU) Second generation endometrial ablation
2004     Health Technology Assessment Section, Ministry of Health Malaysia (MaHTAS) Second generation endometrial ablation techniques
2015     Andalusian Health Technology Assessment Area (AETSA) Second generation prognostic genomic tests in early breast cancer: EndoPredict® y Prosigna™.
2014     Medical Services Advisory Committee (MSAC) Second Opinion for Morphological/Interpretive Pathology
2011     Agency for Healthcare Research and Quality (AHRQ) Second-generation antidepressants in the pharmacologic treatment of adult depression: an update of the 2007 comparative effectiveness review
2018     Agency for Care Effectiveness (ACE) Second-generation antipsychotic injections for treating schizophrenia
2020     Scottish Health Technologies Group (SHTG) Second-generation colon capsule endoscopy (CCE-2) for the detection of colorectal polyps – SHTG Recommendation
2010     Canadian Agency for Drugs and Technologies in Health (CADTH) Second-line therapy for patients with diabetes inadequately controlled on metformin: a systematic review and cost-effectiveness analysis
2015     HAYES, Inc. Second-wave direct-acting antivirals for hepatitis C: ledipasvir-sofosbuvir
2014     HAYES, Inc. Second-wave direct-acting antivirals for hepatitis C: Simeprevir
2015     HAYES, Inc. Second-wave direct-acting antivirals for hepatitis C: Simeprevir
2015     HAYES, Inc. Second-wave direct-acting antivirals for hepatitis C: sofosbuvir
2014     HAYES, Inc. Second-wave direct-acting antivirals for hepatitis C: Sofosbuvir and Ledipasvir
2015     NIHR Health Services and Delivery Research programme Secondary analysis and literature review of community rehabilitation and intermediate care: an information resource
2002     NIHR Horizon Scanning Centre (NIHR HSC) Secretin for autism spectrum disorders - horizon scanning review
2012     NIHR Horizon Scanning Centre (NIHR HSC) Secukinumab for active and progressive psoriatic arthritis
2016     National Institute for Health and Care Excellence (NICE) Secukinumab for active ankylosing spondylitis after treatment with non-steroidal anti-inflammatory drugs or TNF-alpha inhibitors. NICE technology appraisal guidance 407
2012     NIHR Horizon Scanning Centre (NIHR HSC) Secukinumab for ankylosing spondylitis – second line
2012     NIHR Horizon Scanning Centre (NIHR HSC) Secukinumab for moderate to severe, active rheumatoid arthritis
2012     NIHR Horizon Scanning Centre (NIHR HSC) Secukinumab for plaque psoriasis
2021     Scottish Medicines Consortium (SMC) Secukinumab for the treatment of active non-radiographic axial spondyloarthritis with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI) evidence in adults who have responded inadequately to nonsteroidal anti-inflammatory drugs (NSAIDs)
2023     National Institute for Health and Care Excellence (NICE) Secukinumab for treating moderate to severe hidradenitis suppurativa. NICE technology appraisal guidance 935
2015     NIHR Health Technology Assessment programme Secukinumab for treating moderate to severe plaque psoriasis
2021     National Institute for Health and Care Excellence (NICE) Secukinumab for treating moderate to severe plaque psoriasis in children and young people. NICE technology appraisal guidance 734
2015     National Institute for Health and Care Excellence (NICE) Secukinumab for treating moderate to severe plaque psoriasis. NICE technology appraisal guidance 350
2021     National Institute for Health and Care Excellence (NICE) Secukinumab for treating non-radiographic axial spondyloarthritis. NICE technology appraisal guidance 719
2017     National Institute for Health and Care Excellence (NICE) SecurAcath for securing percutaneous catheters. NICE medical technologies guidance 34
2013     Penn Medicine Center for Evidence-based Practice (CEP) Securement devices for peripherally inserted central venous catheters (PICCs) and Midline catheters
2018     Penn Medicine Center for Evidence-based Practice (CEP) Securement of Arterial Catheters
2022     National Institute for Health and Care Excellence (NICE) Sedaconda ACD-S for sedation with volatile anaesthetics in intensive care. NICE medical technologies guidance 65
2022     Swiss Federal Office of Public Health (FOPH) Sedative-hypnotic drugs for the treatment of primary chronic insomnia disorder
2002     University HealthSystem Consortium (UHC) Sedative/hypnotics
2021     National Institute for Health and Care Excellence (NICE) SeHCAT (tauroselcholic [75 selenium] acid) for diagnosing bile acid diarrhoea. NICE diagnostics guidance 44
2013     NIHR Health Technology Assessment programme SeHCAT (Tauroselcholic [75 selenium] acid) for the investigation of bile acid malabsorption (BAM) and measurement of bile acid pool loss
2022     NIHR Health Technology Assessment programme SeHCAT (tauroselcholic [75selenium] acid) for the investigation of bile acid diarrhoea in adults: a systematic review and cost-effectiveness analysis
2020     NIHR Health Technology Assessment programme Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT
2006     HAYES, Inc. Selected dorsal rhizotomy for cerebral palsy
2000     HAYES, Inc. Selected dorsal rhizotomy for cerebral palsy
2018     NIHR Health Technology Assessment programme Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: the DiPEP diagnostic study with decision-analysis modelling
2006     Andalusian Health Technology Assessment Area (AETSA) Selection and evaluation of patient-targeted Websites in the field of healthcare
1999     Healthcare Insurance Board/ College Voor Zorgverzekeringen (CVZ) Selective bowel decontamination before orthotopic liver transplantation - primary research
2008     Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA) Selective cell apheresis in inflammatory bowel disease
2014     NIHR Health Technology Assessment programme Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study)
2002     Wessex Institute for Health Research and Development (WIHRD) Selective denervation for spasmodic torticollis
2006     Medical Services Advisory Committee (MSAC) Selective dorsal rhizotomy (nationally funded centres)
2010     National Institute for Health and Care Excellence (NICE) Selective dorsal rhizotomy for spasticity in cerebral palsy. NICE interventional procedures guidance 373
2011     HAYES, Inc. Selective Estrogen Receptor Modulators (SERMs) for chemoprevention of breast cancer
1999     NIHR Health Technology Assessment programme Selective estrogen receptor modulators for osteoporosis
2004     HAYES, Inc. Selective estrogen receptor modulators for primary breast cancer prevention
2009     HAYES, Inc. Selective head cooling (Olympic Cool-Cap (Natus Medical Inc.) for treatment of perinatal hypoxic-ischemic encephalopathy (HIE)
2009     Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA) Selective IgG Apheresis for ABO-incompatible kidney transplantation. Systematic Review
2021     National Institute for Health and Care Excellence (NICE) Selective internal radiation therapies for treating hepatocellular carcinoma. NICE technology appraisal guidance 688
2020     NIHR Health Technology Assessment programme Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation
2013     Agenzia nazionale per i servizi sanitari regionali (Agenas) Selective Internal Radiation Therapy (SIRT) in colorectal liver metastases
2002     Medical Services Advisory Committee (MSAC) Selective internal radiation therapy for hepatic metastases using SIR-Spheres(R)
2024     National Institute for Health and Care Excellence (NICE) Selective internal radiation therapy for neuroendocrine tumours that have metastasised to the liver. NICE interventional procedures guidance 786
2013     National Institute for Health and Care Excellence (NICE) Selective internal radiation therapy for primary hepatocellular carcinoma. NICE interventional procedures guidance 460
2020     National Institute for Health and Care Excellence (NICE) Selective internal radiation therapy for unresectable colorectal metastases in the liver. NICE interventional procedures guidance 672
2018     National Institute for Health and Care Excellence (NICE) Selective internal radiation therapy for unresectable primary intrahepatic cholangiocarcinoma. NICE interventional procedures guidance 630
2011     Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA) Selective internal radiation therapy using yttrium-90 microspheres for the treatment of primary or metastatic liver malignancies
2024     National Institute for Health and Care Excellence (NICE) Selective internal radiation therapy with QuiremSpheres for treating unresectable advanced hepatocellular carcinoma. NICE technology appraisal guidance 985
2007     HAYES, Inc. Selective laser trabeculoplasty (SLT) using the Selecta 7000 (Lumenis Inc.) for treatment of primary open-angle glaucoma and ocular hypertension
2019     NIHR Health Technology Assessment programme Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT
2008     HAYES, Inc. Selective pancreatectomy for focal congenital hyperinsulinism (CHI)
2004     National Institute for Health and Care Excellence (NICE) Selective peripheral denervation for cervical dystonia. NICE interventional procedures guidance 80
1997     Canadian Coordinating Office for Health Technology Assessment (CCOHTA) Selective serotonin reuptake inhibitors (SSRIs) for major depression. Part 2. The cost-effectiveness of SSRIs in treatment of depression
1997     Canadian Coordinating Office for Health Technology Assessment (CCOHTA) Selective serotonin reuptake inhibitors (SSRIs) for major depression. Part I. Evaluation of the clinical literature
2009     HAYES, Inc. Selective serotonin reuptake inhibitors for the treatment of autism
2010     HAYES, Inc. Selective serotonin reuptake inhibitors in the treatment of post traumatic stress disorder
1999     Alberta Heritage Foundation for Medical Research (AHFMR) Selective testing with bone density measurement
2002     NIHR Horizon Scanning Centre (NIHR HSC) Selective tubal occlusion (Essure) for female sterilisation - horizon scanning review
2001     Canadian Coordinating Office for Health Technology Assessment (CCOHTA) Selective tubal occlusion procedure
2006     Canadian Coordinating Office for Health Technology Assessment (CCOHTA) Selegiline transdermal patch
2012     HAYES, Inc. Selenia dimensions digital tomosynthesis system (Hologic Inc.) for diagnostic mammography
1999     Health Council of the Netherlands Gezondheidsraad (GR) Selenium and its compounds: evaluation of the effects on reproduction, recommendation for classification
2024     Agency for Care Effectiveness (ACE) Selexipag for treating pulmonary arterial hypertension
2010     NIHR Health Technology Assessment programme Self monitoring of blood glucose in type 2 diabetes
1999     Agency for Healthcare Research and Quality (AHRQ) Self-administered drug treatments for acute migraine headache
2018     NIHR Health Technology Assessment programme Self-care support for children and adolescents with long-term conditions: the REfOCUS evidence synthesis
2014     University of York Self-care support for people with COPD
2010     Canadian Agency for Drugs and Technologies in Health (CADTH) Self-directed cognitive behavioural therapy for adults with diagnosis of depression: systematic review of clinical effectiveness, cost-effectiveness, and guidelines
2021     National Institute for Health and Care Excellence (NICE) Self-expanding implant insertion into the intersphincteric space for faecal incontinence. NICE interventional procedures guidance 685
2006     Australian Safety and Efficacy Register of New Interventional Procedures -Surgical (ASERNIP-S) Self-expanding metallic stents (SEMS) for relieving malignant colorectal obstruction: a systematic review
2015     Health Quality Ontario (HQO) Self-management and educational interventions in the postacute stroke population: a rapid review
2018     NIHR Health Technology Assessment programme Self-Management education for adults with poorly controlled epILEpsy [SMILE (UK)]: a randomised controlled trial
2013     Health Quality Ontario (HQO) Self-management support interventions for persons with chronic disease: an evidence-based analysis
2017     NIHR Health Technology Assessment programme Self-management toolkit and delivery strategy for end-of-life pain: the mixed-methods feasibility study
2012     Agency for Healthcare Research and Quality (AHRQ) Self-measured blood pressure monitoring: comparative effectiveness
2019     Swiss Federal Office of Public Health (FOPH) Self-measurement of blood glucose in patients with non-insulin treated diabetes mellitus type 2
2006     HAYES, Inc. Self-monitoring and self-management of oral anticoagulant therapy
2002     HAYES, Inc. Self-monitoring of oral anticoagulant therapy
2007     The Swedish Council on Health Technology Assessment (SBU) Self-testing and self-management of oral anticoagulation - early assessment briefs (Alert)
2024     National Institute for Health and Care Excellence (NICE) Selinexor with bortezomib and dexamethasone for previously treated multiple myeloma. NICE technology appraisal guidance 974
2024     National Institute for Health and Care Excellence (NICE) Selinexor with dexamethasone for treating relapsed or refractory multiple myeloma after 4 or more treatments. NICE technology appraisal guidance 970
2021     National Institute for Health and Care Excellence (NICE) Selinexor with low-dose dexamethasone for treating refractory multiple myeloma (terminated appraisal). NICE technology appraisal guidance 700
2025     National Institute for Health and Care Excellence (NICE) Selpercatinib for advanced thyroid cancer with RET alterations after treatment with a targeted cancer drug in people 12 years and over. NICE technology appraisal guidance 1038
2025     National Institute for Health and Care Excellence (NICE) Selpercatinib for advanced thyroid cancer with RET alterations untreated with a targeted cancer drug in people 12 years and over. NICE technology appraisal guidance 1039
2025     National Institute for Health and Care Excellence (NICE) Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancer. NICE technology appraisal guidance 1042
2022     National Institute for Health and Care Excellence (NICE) Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancer. NICE technology appraisal guidance 760
2021     National Institute for Health and Care Excellence (NICE) Selpercatinib for treating advanced thyroid cancer with RET alterations. NICE technology appraisal guidance 742