Authors' recommendations: Findings originating from published case series and the VENT trial indicate that safety issues remain a concern when inserting EBVs in patients with severe emphysema. The procedure may induce pneumothorax and the presence of a foreign object within the bronchial tree seems to induce COPD exacerbations and to lead to an increased number of hospitalisations during follow-up.No peer-reviewed data from RCTs have been published so far. Some results are available from the minutes of an FDA meeting and some were obtained from one of the manufacturers of the device. These data indicate that the efficacy of EBVs on outcome measures that are important to patients are on average very modest. Subgroups of patients that are yet unidentified, may benefit more substantially from the procedure. This hypothesis is currently being tested in clinical trials.

Project Status: Completed

URL for project: https://kce.fgov.be/publication/report/endobronchial-valves-in-the-treatment-of-severe-pulmonary-emphysema-a-rapid-healt

Year Published: 2009

URL for published report: https://kce.fgov.be/en/endobronchial-valves-in-the-treatment-of-severe-pulmonary-emphysema-a-rapid-health-technology

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Belgium

Organisation Name: Belgian Health Care Knowledge Centre

Contact Address: Administrative Centre Botanique, Doorbuilding (10th floor), Boulevard du Jardin Botanique 55, B-1000 Brussels, Belgium tel: +32 2 287 33 88 fax: +32 2 287 33 85

Contact Name: info@kce.fgov.be

Contact Email: info@kce.fgov.be

Copyright: Belgian Health Care Knowledge Centre (KCE)