Open-label, randomised, parallel-group, multicentre study to evaluate the safety, tolerability and immunogenicity of an AS03B/oil-in-water emulsion- adjuvanted (AS03B) split-virion versus non-adjuvanted whole-virion H1N1 influenza vaccine in UK children 6 months to 12 years of age
Waddington CS, Andrews N, Hoschler K, Walker WT, Oeser C, Reiner A, John T, Wilkins S, Casey M, Eccleston PE, Allen RJ, Okike I, Ladhani S, Sheasby E, Waight P, Collinson AC, Heath PT, Finn A, Faust SN, Snape MD, Miller E, Pollard AJ
Record ID 32010001172
English
Authors' recommendations:
In this first direct comparison of an AS03B-adjuvanted split-virion vaccine versus whole-virion non-adjuvanted H1N1 vaccine, the adjuvanted vaccine – while reactogenic – was more immunogenic, especially in younger children, indicating the potential for improved immunogenicity of influenza vaccines in this age group.
Details
Project Status:
Completed
URL for project:
http://www.hta.ac.uk/fullmono/mon1446.pdf#nameddest=article01
Year Published:
2010
URL for published report:
http://www.hta.ac.uk/project/2225.asp
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Child
- Child, Preschool
- Drug Therapy, Combination
- Emulsions
- Female
- Immunization Programs
- Infant
- Male
- Program Evaluation
- Antibodies, Viral
- Disease Outbreaks
- Influenza A Virus, H1N1 Subtype
- Influenza Vaccines
- Influenza, Human
- Polysorbates
- Squalene
- alpha-Tocopherol
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
2010 Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.