TheraGuide 5-FU (Myriad Genetic Laboratories Inc.) for predicting toxicity to 5-Fluorouracil (5-FU) / Capecitabine-based Chemotherapy

Record ID 32010000878
English
Authors' objectives:

Chemotherapeutic agents 5-fluorouracil (5-FU) (Adrucil®; SP Pharmaceuticals) and capecitabine (Xeloda®; Roche Laboratories Inc.) are used for the treatment of a range of tumors, including those in the colon (both agents), rectum (5-FU), breast (both agents), stomach (5-FU), and pancreas (5-FU). Toxicity, including hand-foot syndrome, diarrhea, stomatitis, neutropenia, and neurotoxicity, has been reported with both agents. Capecitabine is a synthetic precursor of 5-FU, which was developed to provide a less toxic alternative to 5-FU. The primary mechanism of 5-FU is inhibition of thymidylate synthase. The thymidylate synthase gene (TYMS) is located at chromosome 18 at band p11.32. In vivo enzymatic catabolism of 5-FU is performed by dihydropyrimidine dehydrogenase, whose gene DPYD is located at chromosome 1 at band p22. Functional variants in TYMS and DPYD are implicated in 5-FU/capecitabine-based treatment toxicity. The TheraGuide 5-FU test analyzes the entire coding region of DPYD for clinically significant sequence variants, as
well as a specific variant (c.-97_-70(2_3)) located in the 5’ untranslated region (UTR) of the TYMS gene.

Details
Project Status: Completed
URL for project: http://www.hayesinc.com/
Year Published: 2009
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Antineoplastic Combined Chemotherapy Protocols
  • Chemotherapy, Adjuvant
Contact
Organisation Name: HAYES, Inc.
Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name: saleinfo@hayesinc.com
Contact Email: saleinfo@hayesinc.com
Copyright: 2009 Winifred S. Hayes, Inc
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