Rapid testing and targeted population screening for Helicobacter pylori

Mundy L, Braunack-Mayer A, Hiller JE
Record ID 32010000758
Authors' results and conclusions: Although a large proportion of all gastric cancers are associated with H pylori infection, not all H pylori infected individuals will go on to develop cancer; however it has been suggested that 60-80% of gastric cancers could be prevented by H pylori eradication. Numerous diagnostic methods are available for the detection of H pylori including non-invasive tests: rapid stool antigen test (enzyme-linked immunosorbant assay or immunochromatographic tests), urea breath test or serology. Invasive tests include the gold standard endoscopy followed by histology, endoscopy followed by culture or the rapid urease test. Rapid H pylori diagnostic tests are intended to provide a swift, accurate, non-invasive and inexpensive means of identifying individuals currently infected with H pylori which ideally would be able to be used in a point-of-care context in clinics or a general practitioner's office.
Authors' recomendations: Immunochromatographic (ICT) and enzyme-linked immunosorbent assay (ELISA) rapid stool antigen tests for H pylori may have potential as a diagnostic tool for this infection, but currently are not as sensitive or as specific as the urea breath test. HealthPACT did not find evidence to support the introduction of rapid stool antigen tests for screening for H pylori infection in the Australian and New Zealand population, and supports the current approach of a targeted 'test and treat' strategy for individual patients considered to be at risk of this infection.
Project Status: Completed
Year Published: 2009
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Australia
MeSH Terms
  • Mass Screening
  • Helicobacter Infections
Organisation Name: Adelaide Health Technology Assessment
Contact Address: School of Public Health, Mail Drop 545, University of Adelaide, Adelaide SA 5005, AUSTRALIA, Tel: +61 8 8313 4617
Contact Name: ahta@adelaide.edu.au
Contact Email: ahta@adelaide.edu.au
Copyright: Adelaide Health Technology Assessment (AHTA)
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