Authors' recommendations: The clinical validity and clinical utility of serologic tests for celiac disease was considered high in subjects with symptoms consistent with the disease as they aid in the diagnosis of celiac disease and some tests present a high accuracy, and a celiac disease diagnosis leads to treatment with a gluten-free diet.The study findings suggest that IgA tTG is the most accurate and the most cost-effective test.IGA AGA has a lower accuracy compared to other IgA-based serologic celiac disease tests.Serologic test combinations appear to be more costly with little gain in accuracy.IgA deficiency seems to be uncommon in patients diagnosed with celiac disease.The generalizability of study results is contingent on performing both the serologic test and biopsy in subjects on a gluten-containing diet, since the avoidance of gluten may affect test results.

Project Status: Completed

Year Published: 2010

URL for published report: http://www.health.gov.on.ca/english/providers/program/mas/tech/reviews/pdf/rev_celiac_20101210.pdf

URL for additional information: http://www.hqontario.ca/en/mas/mas_ohtas_tech_celiac_20101210.html

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Medical Advisory Secretariat

Contact Address: Medical Advisory Secretariat, 20 Dundas Street West, 10th Floor, Toronto, ON M5G 2N6 CANADA. Tel: 416-314-1092l; Fax: 416-325-2364;

Contact Name: MASinfo.moh@ontario.ca

Contact Email: MASinfo.moh@ontario.ca

Copyright: Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care (MAS)