[Detection of high risk human papillomavirus E6 and E7 oncogenes for cervical cancer screening]
Varela Lema L, Queiro Verdes T
Record ID 32010000672
Spanish
Authors' objectives:
The principal objective of this report was to assess the effectiveness of the various HPV E6 E7 mRNA detection methods in cervical cancer screening. The specific objectives were to assess the effectiveness of HPV E6 E7 mRNA detection methods in different clinical applications, i.e., when used: 1) as the primary screening method; 2) for triage of women with inconclusive results or low-grade intraepithelial lesions; and 3) for triage of women with positive results in HPV DNA tests.
Authors' recommendations:
1) HPV mRNA methods cannot be regarded as a primary screening test owing to the low sensitivity displayed by these methods in many of the studies undertaken. 2) Despite the potential interest of these tests in triage of women with inconclusive results or low-grade intraepithelial lesions or normal women with HPV (+) results, there is not sufficient evidence to establish whether these techniques amount to an improvement with respect to cytology and/or HPV DNA. 3) The practical totality of the studies used the PreTec HPVProofer test and it is not known whether techniques that detect a greater number of genotypes or do so quantitatively yield better results.
Details
Project Status:
Completed
Year Published:
2010
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Spain
MeSH Terms
- Mass Screening
- Papillomavirus E7 Proteins
- Uterine Cervical Neoplasms
Contact
Organisation Name:
Scientific Advice Unit, avalia-t; The Galician Health Knowledge Agency (ACIS)
Contact Address:
Conselleria de Sanidade, Xunta de Galicia, San Lazaro s/n 15781 Santiago de Compostela, Spain. Tel: 34 981 541831; Fax: 34 981 542854;
Contact Name:
avalia-t@sergas.es
Contact Email:
avalia-t@sergas.es
Copyright:
Galician Agency for Health Technology Assessment (AVALIA-T)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.