Health technology assessment of thiopurine methyltransferase testing for guiding 6-mercaptopurine doses in pediatric patients with acute lymphoblastic leukemia

Donnan JR, Ungar WJ, Mathews M, Hancock-Howard RL.
Record ID 32010000458
English
Authors' recommendations: Neither of the testing interventions (genotyping and phenotyping) showed a benefit in survival compared to standard dosing. Both testing strategies were more costly compared to standard weight-based dosing. A probabilistic sensitivity analysis found that the mean costs per child of the standard, phenotyping and genotyping strategies were $669 (95% CI 547, 791), $967 (95% CI 721, 1,213), and $946 (95% CI 659, 1,233), respectively. Incremental costs for phenotyping-standard were: $298 (95% CI 116, 480), for genotyping-standard $277 (95% CI 73, 481) and for genotyping-phenotyping -$21 (95% CI -343, 301). The PSA demonstrated that the cost differences between the phenotyping and genotyping tests are likely negligible. The univariate sensitivity analysis showed that the incremental costs between the strategies may be affected by changes in the price of the genotyping and phenotyping tests. At this time there is insufficient evidence to recommend routine phenotype or genotype testing prior to 6-MP therapy to guide initial doses in pediatric ALL patients
Details
Project Status: Completed
Year Published: 2010
URL for published report: https://lab.research.sickkids.ca/task/wp-content/uploads/sites/66/2018/06/2010-02-TPMT-LEUKEMIA-FULL-REPORT.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Leukemia
  • Methyltransferases
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
Contact
Organisation Name: Technology Assessment at SickKids
Contact Address: Program of Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 tel: (416) 813-8519 fax: (416) 813-5979
Contact Name: wendy.ungar@sickkids.ca
Contact Email: wendy.ungar@sickkids.ca
Copyright: The Hospital for Sick Children Research Institute
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.