Authors' objectives: The systematic review has two objectives. 1) To evaluate the clinical effects, safety and cost-effectiveness of 'atypical' antipsychotics, compared to conventional drugs, placebo and other atypical drugs. 2) To investigate response in people with 'treatment resistant' schizophrenia, people with predominantly negative symptoms and people experiencing their first episode of schizophrenia. In addition, an economic model will be constructed using data from the systematic review of clinical effectiveness. Search strategies will focus on retrieving randomised controlled trials of the following atypical antipsychotics: Aripiprazole, L-745870, Melperon, Piquindone hydrochloride, Sertindole, Ziprasidone, Zotepine, Thioridazine, Loxapine, Amisulpiride and Methotrimeprazine. Relevant electronic databases will be searched and reference lists of retrieved papers scanned. This will include a search of electronic conference proceedings. Experts working in the field and pharmaceutical companies will be contacted. Searches will not be restricted by language or by country of origin of trials.

Project Status: Completed

URL for project: https://www.journalslibrary.nihr.ac.uk/programmes/hta/961899/#/

Year Published: 2003

URL for published report: https://www.journalslibrary.nihr.ac.uk/programmes/hta/961899/#/

Requestor: NIHR Health Technology Assessment programme

English language abstract: An English language summary is available

Publication Type: Full HTA

Country: England, United Kingdom

Pubmed ID: 12925268

Organisation Name: NIHR Health Technology Assessment programme

Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK

Contact Name: journals.library@nihr.ac.uk

Contact Email: journals.library@nihr.ac.uk

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