The Percutaneous shunting in Lower Urinary Tract Obstruction (PLUTO) study and randomised controlled trial: evaluation of the effectiveness, cost-effectiveness and acceptability of percutaneous vesicoamniotic shunting for lower urinary tract obstruction
Morris R, Malin G, Quinlan-Jones E, Middleton Lj, Diwakar L, Hemming K, Burke D, Daniels J, Denny E, Barton P, Roberts T, Khan K, Deeks J, Kilby M
Record ID 32010000415
English
Authors' objectives:
To determine the effectiveness, cost-effectiveness and patient acceptability of VAS for fetal LUTO.
Authors' recommendations:
Survival to 28 days and 1 year appears to be higher with VAS than with conservative management, but it is not possible to prove benefit beyond reasonable doubt. Notably, prognosis in both arms for survival and renal function is poor. VAS was substantially more costly and unlikely to be regarded as cost-effective based on the 1-year data. Parents should be counselled about the risks of pregnancy loss with or without VAS insertion. The National Institute for Health and Care Excellence interventional procedures guidance (IPG 202) should be updated to reflect this new evidence. Babies in the PLUTO trial should be followed up long term for the different outcomes.
Details
Project Status:
Completed
URL for project:
http://www.nets.nihr.ac.uk/projects/hta/070144
Year Published:
2013
URL for published report:
http://www.journalslibrary.nihr.ac.uk/hta/hta17590/#/abstract
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Adult
- Bayes Theorem
- Cost-Benefit Analysis
- Female
- Follow-Up Studies
- Infant, Newborn
- Male
- Maternal Age
- Perinatal Mortality
- Pregnancy
- Registries
- Survival Analysis
- Ultrasonography, Prenatal
- Young Adult
- Abortion, Induced
- England
- Fetal Diseases
- Kidney Failure, Chronic
- Netherlands
- Pregnancy Outcome
- Research Subjects
- Scotland
- Urinary Bladder Neck Obstruction
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
<p>2010 Queen's Printer and Controller of HMSO</p>
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.