A randomised controlled trial of the probiotic Bifidobacterium breve BBG-001 in preterm babies to prevent sepsis, necrotising enterocolitis and death: the Probiotics in Preterm infantS (PiPS) trial
Record ID 32010000378
English
Authors' objectives:
To test the use of the probiotic Bifidobacterium breve strain BBG-001 to prevent necrotising enterocolitis (NEC), late-onset sepsis and death in preterm babies while monitoring probiotic colonisation of participants.
NEC and late-onset sepsis remain important causes of death and morbidity in preterm babies. Probiotic administration might strengthen intestinal barrier function and provide protection; this is supported by published meta-analyses, but there is a lack of large well-designed trials.
Authors' recommendations:
This is the largest trial to date of a probiotic intervention. It shows no evidence of benefit and does not support routine use of probiotics for preterm infants.
Details
Project Status:
Completed
URL for project:
http://www.nets.nihr.ac.uk/projects/hta/0550104
Year Published:
2016
URL for published report:
http://www.journalslibrary.nihr.ac.uk/hta/hta20660/#/abstract
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Infant, Premature
- Enterocolitis, Necrotizing
- Probiotics
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
<p>2010 Queen's Printer and Controller of HMSO</p>
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.