VenUS IV (Venous leg Ulcer Study IV) - compression hosiery compared with compression bandaging in the treatment of venous leg ulcers: a randomised controlled trial, mixed-treatment comparison and decision-analytic model

Ashby R, Gabe R, Ali S, Saramago P, Chuang L, Adderley U, Bland M, Cullum N, Dumville J, Iglesias Urrutia C, Kang'ombe A, Soares M, Stubbs N, Torgerson DJ
Record ID 32010000357
English
Authors' objectives: Part I - To compare the clinical effectiveness and cost-effectiveness of HH and 4LB in terms of time to complete healing of venous leg ulcers. Part II - To synthesise the relative effectiveness evidence (for ulcer healing) of high-compression treatments for venous leg ulcers using a mixed-treatment comparison (MTC). Part III - To construct a decision-analytic model to assess the cost-effectiveness of high-compression treatments for venous leg ulcers.
Authors' recommendations: Trial data from VenUS IV found no evidence of a difference in venous ulcer healing between HH and the 4LB. HH may reduce ulcer recurrence rates compared with the 4LB and be a cost-effective treatment. When all available high-compression treatments were considered, the 2LB had the highest probability of being clinically effective and cost-effective. However, the underpinning evidence was sparse and more research is needed. Further research should thus focus on establishing, in a high-quality trial, the effectiveness of this compression system in particular.
Details
Project Status: Completed
URL for project: http://www.hta.ac.uk/1766
Year Published: 2014
URL for published report: http://www.journalslibrary.nihr.ac.uk/hta/hta18570/#/abstract
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Bandages
  • Leg Ulcer
  • Stockings, Compression
  • Varicose Veins
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: <p>2010 Queen's Printer and Controller of HMSO</p>
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