A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population. Quality of life at 5 years in the PRIME trial

Williams L, Kunkler I, King C, Jack W, van der Pol M
Record ID 32010000287
English
Authors' objectives:

To assess whether omission of post-operative radiotherapy (RT) in women with ‘low-risk’ axillary node-negative early breast cancer [tumour size of < 5 cm (T0–2) although the eligibility criteria further reduce the eligible size to a maximum of 3 cm] treated by breast-conserving surgery and adjuvant endocrine therapy improves quality of life and is more cost-effective.

Authors' recommendations: Study found that radiotherapy was well tolerated, but did not have a significant impact on overall health-related quality of life or anxiety and depression; although there were favourable impacts on some aspects of quality of life. Effects associated with radiotherapy were larger closer to the time of treatment. In the longer term increased breast symptoms were apparent after radiotherapy although these had subsided in both groups by three years after treatment.
Details
Project Status: Completed
URL for project: http://www.hta.ac.uk/1697
Year Published: 2011
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Aged
  • Breast Neoplasms
  • Postoperative Care
  • Radiotherapy, Adjuvant
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: 2011 Queen’s Printer and Controller of HMSO
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