Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of Technology Appraisal No. 90): a systematic review and economic analysis

Greenhalgh J, Bagust A, Boland A, Martin Saborido C, Oyee J, Blundell M, Dundar Y, Dickson R, Proudlove C, Fisher M
Record ID 32010000274
English
Authors' objectives:

This review assessed the clinical effectiveness and cost-effectiveness of clopidogrel and modified-release dipyridamole (MRD) alone or with aspirin (ASA) compared with ASA (and each other, where appropriate) in the prevention of occlusive vascular events in patients with a history of MI or ischaemic stroke/TIA, peripheral arterial disease and multivascular disease.

This review is an update of guidance Technology Appraisal No. 90 (TA90) produced the by National Institute for Health and Clinical Excellence (NICE).

Authors' recommendations: Review evidence suggests that the most cost-effective treatment approach for the prevention of future occlusive vascular events is: in ischaemic stroke/transient ischaemic attack patients is clopidogrel (CLOP) followed by modified-release dipyridamole plus aspirin (ASA) and then ASA alone; in myocardial infarct (heart attack) patients is ASA followed by CLOP; and for patients with established peripheral arterial disease or multivascular disease is CLOP followed by ASA.
Details
Project Status: Completed
URL for project: http://www.hta.ac.uk/2118
Year Published: 2011
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Platelet Aggregation Inhibitors
  • Treatment Outcome
  • Vascular Diseases
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: 2011 Queen’s Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.