Accuracy of bacterial DNA testing for central venous catheter-associated bloodstream infection in children with cancer
Millar M, Zhou W, Skinner R, Pizer B, Hennessy E, Wilks M, Gilbert RE
Record ID 32010000268
English
Authors' objectives:
1.To determine the diagnostic accuracy of a novel molecular test for CVC-associated infection in children with cancer admitted with fever.
2.To determine the extent to which bacterial DNA and other prognostic markers discriminate between sequelae of CVC-associated infection, including CVC removal and duration of i.v. antibiotic treatment days.
3.To conduct systematic reviews to determine the effectiveness of treatment options targeted at CVC-associated bloodstream infection.
4.To survey current clinical practice to determine the use of antimicrobial locks for prophylaxis or treatment of CVC-associated infection and perceived barriers to their use.
5.To estimate the potential benefits of different test–treatment strategies measured by i.v. antibiotic treatment days saved and avoidance of unnecessary CVC removals.
Authors' recommendations:
Study found strong evidence to support the use of antimicrobial lock solutions for prevention of central venous catheter (CVC)-associated infection. The study found no evidence to support routine bacterial DNA testing for children with cancer admitted with fever to detect CVC-associated infection. Further research is needed to determine the value of repeated bacterial testing in high-risk groups.
Details
Project Status:
Completed
Year Published:
2011
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Bacteremia
- Risk Management
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
2011 Queen’s Printer and Controller of HMSO