Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation

Cooper KL, Meng Y, Harnan S, Ward SE, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson ID, Lorenz E
Record ID 32010000253
English
Authors' objectives:

The objectives of this assessment were to evaluate the diagnostic accuracy, cost-effectiveness and effect on patient outcomes of positron emission tomography (PET), with or without computed tomography (CT), and magnetic resonance imaging (MRI) in the evaluation of axillary lymph node metastases in patients with newly diagnosed early-stage breast cancer. PET and MRI are assessed firstly as a replacement for SLNB or 4-NS, and secondly as an additional test prior to SLNB or 4-NS.

Authors' recommendations: Study found that ultrasmall super-paramagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) for detection of axillary lymph node metastases in early breast cancer may have similar diagnostic accuracy to current surgical techniques (sentinel lymph node biopsy and 4-node sampling), and that MRI was more cost-effective owing to reduction in adverse events. MRI had greater sensitivity than positron emission tomography (PET) in this setting.
Details
Project Status: Completed
URL for project: http://www.hta.ac.uk/1848
Year Published: 2011
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Axilla
  • Lymph Nodes
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: 2011 Queen’s Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.