Clinical utility of serologic testing for celiac disease in asymptomatic patients: an evidence-based analysis
Medical Advisory Secretariat
Record ID 32010000197
English
Authors' objectives:
The objective of this evidence-based analysis was to evaluate the clinical utility of serologic testing for celiac disease in asymptomatic individuals presenting with one of the non-gastrointestinal conditions evaluated in this report. The clinical utility was based on the effects of a gluten-free diet (GFD) on outcomes specific to each of these conditions. The prevalence of celiac disease in asymptomatic individuals and one of these non-gastrointestinal conditions was also evaluated.
Authors' recommendations:
Based on a review of the literature, there is an increased risk of asymptomatic celiac disease in patients with type 1 diabetes.Based on low quality evidence, in patients with idiopathic short stature and asymptomatic celiac disease there is an acceleration in growth once a gluten-free diet is introduced.With the exception of idiopathic short stature, there was no published evidence of clinical utility of celiac disease testing in asymptomatic patients with respect to a gluten-free diet intervention in the other conditions evaluated.Based on low to very low quality evidence, asymptomatic celiac disease does not confer an increased risk of lymphoma or mortality.Similarly, in patients with lymphoma there is no increased risk of asymptomatic celiac disease.
Details
Project Status:
Completed
Year Published:
2011
URL for published report:
http://www.health.gov.on.ca/english/providers/program/mas/tech/reviews/pdf/rev_celiac_disease_asymptomatic_20110705.pdf
URL for additional information:
http://www.hqontario.ca/en/mas/mas_ohtas_tech_celiac_disease_asymptomatic_20110705.html
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Canada
- Predictive Value of Tests
Contact
Organisation Name:
Medical Advisory Secretariat
Contact Address:
Medical Advisory Secretariat, 20 Dundas Street West, 10th Floor, Toronto, ON M5G 2N6 CANADA. Tel: 416-314-1092l; Fax: 416-325-2364;
Contact Name:
MASinfo.moh@ontario.ca
Contact Email:
MASinfo.moh@ontario.ca
Copyright:
Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care (MAS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.