Islet transplantation for the treatment of Type 1 diabetes - an update
Guo B, Corabian P, Harstall C
Record ID 32009100009
English
Authors' objectives:
1) to assess clinical research evidence on the safety and efficacy/effectiveness of islet transplantation alone (ITA) for patients with non-uremic type 1 diabetes with severe hypoglycemia or hypoglycemia unawareness;
2) to assess research evidence on the comparability of ITA with intensive insulin therapy or whole organ pancreas transplantation in reducing hypoglycemia episodes and restoring insulin independence in this group of patients.
Authors' recommendations:
The definition of success for islet transplantation remains controversial. Insulin independence may not be an appropriate clinical outcome for islet transplantation. Islet transplantation should aim at reducing the doses of required insulin therapy and the frequency of severe hypoglycemia events; these outcomes would improve patients' quality of life and would improve glycemic control to prevent long-term diabetic complications.
Islet transplantation is a complex procedure that has undergone continuous evolution over the past decade. It offers an alternative treatment option for a small group of patients with severe hypoglycemia, hypoglycemia unawareness, and brittle diabetes, who have failed to respond to standard treatment and management. Its safety and efficacy/effectiveness in these highly select patients has been extensively investigated. The role of islet transplantation in the long-term treatment of T1DM has yet to be determined because of the potential risk of immunosuppression-related side effects, the absence of sustained long-term treatment effects, and the insufficient supply of donor pancreata.
Details
Project Status:
Completed
Year Published:
2008
URL for published report:
http://www.ihe.ca/advanced-search/islet-transplantation-for-the-treatment-of-type-1-diabetes-an-update
URL for additional information:
http://www.health.alberta.ca/initiatives/health-evidence-reviews-list.html
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Diabetes Mellitus, Type 1
- Islets of Langerhans
- Islets of Langerhans Transplantation
- Humans
Contact
Organisation Name:
Institute of Health Economics
Contact Address:
1200, 10405 – Jasper Avenue, Edmonton, AB T5J 3N4, Canada. Tel: +1 780 448 4881 Fax: +1 780 448 0018
Contact Name:
info@ihe.ca
Contact Email:
info@ihe.ca
Copyright:
Institute of Health Economics (IHE)
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