[Autologous chondrocyte implantion. An updated systematic review and tutelage use extension]
Perez Cachafeiro S, Ruano Ravina A
Record ID 32008100091
To assess the efficacy, safety and costs of ACI and MACI applied to the treatment of knee and ankle chondral lesions
Authors' results and conclusions: Two independent investigators selected 24 articles according to previously established selection criteria. These papers are three clinical trials, two cohort studies, fifteen case series studies, three systematic reviews and one economic evaluation. Two clinical trials compare ACI with its variant MACI, and the third one compares ACI with mosaicplasty. A cohort study evaluates ACI against debridement, while the other assesses different ways of implementing ACI. Just one study was related to the ankle joint; and another one was an economic evaluation; although a systematic review also includes an economic model.
Authors' recomendations: ACI efficacy has yet to be proved better for knee osteochondral lesions than other procedures efficacies. In the short term (2-3 years), ACI and MACI patients’ knee conditions improve. ACI is a safe procedure. Nevertheless, the new variant (MACI) could be safer since it presents fewer hypertrophy-related adverse events. The effectiveness of ACI and MACI has to be proved through randomized clinical trials, for both knee and ankle joints. Patients with associated joint diseases have to undergone correction of those in conjunction with ACI.
Authors' methods: Systematic review
Project Status: Completed
URL for project: http://www.sergas.es/MostrarContidos_N3_T02.aspx?IdPaxina=60518&uri=/Docs/Avalia-t/InfImpCondroc.pdf&hifr=1000&seccion=0
Year Published: 2008
English language abstract: An English language summary is available
Publication Type: Not Assigned
Organisation Name: Scientific Advice Unit, avalia-t; The Galician Health Knowledge Agency (ACIS)
Contact Address: Conselleria de Sanidade, Xunta de Galicia, San Lazaro s/n 15781 Santiago de Compostela, Spain. Tel: 34 981 541831; Fax: 34 981 542854;
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Copyright: Galician Agency for Health Technology Assessment (AVALIA-T)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.