[Establishing standards, records and analytical procedures for the treatment of ulcerative colitis]

Ibargoyen-Roteta N, Gutierrez-Ibarluzea I, Cabriada-Nunez JL, Clofent-Vilaplana J, Ginard-Vicens D, Domenech-Morral E, Oliva-Oliva G, Queiro-Verdes T
Record ID 32008100082
Original Title: Establecimiento de estándares, registro y análisis de casos de tratamiento de la colitis ulcerosa mediante sistemas de aféresis
Authors' objectives: The aims of this study are as follows: a) to establish standards for treatment with ulcerative colitis (UC) apheresis systems; b) establish a system to monitor their use and c) analyse the efficiency and safety of its use in these patients.
Authors' results and conclusions: In the review update, 37 studies of interest have been found. To assess the efficiency and safety of apheresis systems in UC, 12 controlled clinical tests have finally been selected, although, given the importance of safety in a monitored technique, the results of 18 series of cases have also been included. The variables included in the database have been defined by consensus. This database has been distributed to hospitals interested in this study. In view of the fact that this is a prospective and long-term monitoring project(more than 12 months), cases carried out since the database was implemented have been included.
Authors' recommendations: Although there is still no quality evidence to show that apheresis is more effective than the conventional treatment in UC, it seems that this does not have a placebo effect and that it is safe and efficient in the withdrawal of corticoids. Moreover, data recovered regarding suitability shows that treatment of corticodependent UC with Adacolumn® may be accepted by the Health System. Due to its safety and current use, it is an optimum treatment for monitoring purposes, although to do this, it is essential to involve health care professionals, hospitals and health services.
Authors' methods: The systematic review carried out by Osteba in 2004 to assess the quality of the scientific evidence found, has been updated. A system to monitor the use of these systems in the treatment of UC has been designed and implemented. This consists of an online database with standards for indicating and collecting cases and a web site that houses the database and is used as an information point and link to participating hospitals. The data obtained will allow a descriptive analysis to be made of the variables studied and subsequently it will be possible to determine the characteristics of patients the best respond to the treatment.
Project Status: Completed
Year Published: 2008
English language abstract: An English language summary is available
Publication Type: Rapid Review
Country: Spain
  • Ulcerative Colitis
  • Apheresis
  • Physiological Monitoring
  • Monitorización Fisiológica
  • Aféresis
  • Colitis Ulcerosa
Organisation Name: Basque Office for Health Technology Assessment
Contact Address: C/ Donostia – San Sebastián, 1 (Edificio Lakua II, 4ª planta) 01010 Vitoria - Gasteiz
Contact Name: Lorea Galnares-Cordero
Contact Email: lgalnares@bioef.eus
Copyright: <p>Basque Office for Health Technology Assessment, Health Department Basque Government (OSTEBA)</p>
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