[Therapeutic hypothermia following perinatal asphyxia]
Swedish Council on Technology Assessment in Health Care
Record ID 32008100078
Swedish
Authors' objectives:
What effects does therapeutic hypothermia have on mortality and survival with moderate or severe functional disabilities in full-term infants affected by moderate or severe symptoms of hypoxic ischemic encephalopathy (HIE) following serious birth asphyxia?
What are the potential complications and adverse effects of treatment?
What does the treatment cost? Is it cost-effective?
Authors' recommendations:
In full-term newborns affected by moderate or severe symptoms of brain injury (HIE) due to severe birth asphyxia, therapeutic hypothermia reduces the risk of death or severe functional impairment in the child (Evidence Grade 2). However, the scientific evidence is insufficient to appraise the method’s effect beyond 18 months.The scientific evidence is insufficient to draw firm conclusions on the adverse effects and complications related to therapeutic hypothermia. No serious adverse effects or complications have been identified in the studies reviewed for this report, but the studies were not specifically designed to investigate this.The scientific evidence is insufficient to draw firm conclusions on the cost-effectiveness of the method. However, the fact that the extra costs for this method are relatively moderate and the outcomes are good would suggest that the method is cost-effective.The optimum way (best practice) to deliver treatment is not clear. Hence, it is important to monitor the experiences and outcomes of treatment, eg, via a central quality register. Also, continued research is essential to gain knowledge about best practices as well as the potential complications and adverse effects.
Authors' methods:
Review
Details
Project Status:
Completed
URL for project:
www.sbu.se/200901e
Year Published:
2009
URL for published report:
www.sbu.se/200901
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Sweden
MeSH Terms
- Infant, Newborn
- Asphyxia Neonatorum
- Hypothermia, Induced
Contact
Organisation Name:
Swedish Agency for Health Technology Assessment and Assessment of Social Services
Contact Address:
P.O. Box 3657, SE-103 59 Stockholm, Sweden. Tel: +46 8 4123200, Fax: +46 8 4113260
Contact Name:
registrator@sbu.se
Contact Email:
registrator@sbu.se
Copyright:
Swedish Council on Technology Assessment in Health Care (SBU)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.