[Prenatal screening of down syndrome]

Lopez de Argumedo M, Egues N, Lapuente JL
Record ID 32008000095
Spanish
Original Title: Cribado prenatal del Síndrome de Down
Authors' objectives: • Assess the performance of serological and echographical markers used for screening Down syndrome. • Determine the safety issues associated with these possible alternatives. • Identify the preferences of women with regard to DS screening. • Analyse the implications that a hypothetical introduction of DS screening would have for the organisation of public health in the Basque Community. • Identify the most cost-effective option.
Authors' results and conclusions: There is sufficient good-quality evidence to demonstrate that the highest-performing tests are the Integrated Test and Integrated Serum Test. These involve detection rates of over 75% with false-positive rates of around 1%. There are other alternatives with similar detection levels, but with higher false-positive rates. In accordance with the analyzed studies women prefer screening tests that reduce the period of uncertainty and provide early detection. The tests that offer the highest levels of effectiveness and reliability (Integrated and Integrated Serum Tests) do not comply with this requirement as screening tests are not issued until the 2nd trimester tests have been completed. A high percentage of high-risk women insist on having a reliable diagnosis. According to our analysis, the most cost-effective strategy is the Two Stage Strategy in the 1st trimester, followed by the Integrated Test and the Combined Test, which offer similar cost effectiveness values.
Authors' methods: For objetives 1, 2 and 3: A bibliographical search was made to find relevant scientific evidence. For objetives 4 and 5: Cost effectiveness study.
Details
Project Status: Completed
Year Published: 2007
URL for published report: https://www.euskadi.eus/contenidos/informacion/2007_osteba_publicacion/es_def/adjuntos/d_07-04_inform_SinDown.pdf
English language abstract: An English language summary is available
Publication Type: Mini HTA
Country: Spain
MeSH Terms
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Down Syndrome
  • Mass Screening
Keywords
  • Down Syndrome
  • Mass Screening
  • Prenatal Diagnosis
  • Prenatal Care
  • Early Diagnosis
  • Nuchal Translucency Measurement
  • Chorionic Villi Sampling
Contact
Organisation Name: Basque Office for Health Technology Assessment
Contact Address: C/ Donostia – San Sebastián, 1 (Edificio Lakua II, 4ª planta) 01010 Vitoria - Gasteiz
Contact Name: Lorea Galnares-Cordero
Contact Email: lgalnares@bioef.eus
Copyright: <p>Basque Office for Health Technology Assessment, Health Department Basque Government (OSTEBA)</p>
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