The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients

Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C
Record ID 32007000879
Authors' objectives: To quantify the effects of early administration of TXA on death, vascular occlusive events and the receipt of blood transfusion in trauma patients
Authors' recommendations: Study found that early administration of tranexamic acid safely reduced the risk of death in bleeding trauma patients and is highly cost-effective.
Project Status: Completed
Year Published: 2013
URL for published report:
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Blood Transfusion
  • Fatal Outcome
  • Multiple Trauma
  • Randomized Controlled Trial
  • Treatment Outcome
  • Wounds and Injuries
  • Antifibrinolytic Agents
  • Hemorrhage
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
Contact Email:
Copyright: 2013 Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.