Randomised controlled trial of

Randomised controlled trial of Tumour necrosis factor inhibitors Against Combination Intensive Therapy with conventional disease-modifying antirheumatic drugs in established rheumatoid arthritis: the TACIT trial and associated systematic reviews

Scott D, Ibrahim F, Farewell V, O'Keeffe A, Ma M, Walker D, Heslin M, Patel A, Kingsley G.

Record ID 32007000877

English

Authors' objectives: We assessed whether or not combination DMARDs (cDMARDs) give equivalent clinical benefits at lower costs in RA patients eligible for TNFis.

Authors' recommendations: Active RA patients who have failed methotrexate and another DMARD achieve equivalent clinical benefits at a lower cost from starting cDMARDs or from starting TNFis (reserving TNFis for non-responders). Only a minority of patients achieve sustained remission with cDMARDs or TNFis; new strategies are needed to maximise the frequency of remission.

Details

Project Status: Completed

URL for project: http://www.hta.ac.uk/1606

Year Published: 2014

URL for published report: http://www.journalslibrary.nihr.ac.uk/hta/hta18660/#/abstract

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: England, United Kingdom

MeSH Terms

Randomized Controlled Trial
Treatment Outcome
Antibodies, Monoclonal
Anti-Inflammatory Agents
Antirheumatic Agents
Arthritis, Rheumatoid
Tumor Necrosis Factor-alpha

Contact

Organisation Name: NIHR Health Technology Assessment programme

Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK

Contact Name: journals.library@nihr.ac.uk

Contact Email: journals.library@nihr.ac.uk

This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.