Authors' objectives:

"The purpose of this report is to assess the clinical effectiveness and cost-effectiveness of CRT for people with heart failure and evidence of dyssynchrony by comparing CRT-P and CRT-D devices each with OPT, and with each other." (from executive summary)

Authors' recommendations: In the population considered in this review, CRT-P and CRT-D devices reduce mortality and hospitalisations due to heart failure, improve quality of life and additionally CRT-D devices reduce sudden cardiac death in people with heart failure NYHA classes III and IV, in sinus rhythm with QRS >120 ms. When measured using a lifetime time horizon and compared with optimal medical therapy, the devices (CRT-P ICER UKP16,735, CRT-D ICER UKP23,650) are estimated to be cost-effective at a WTP threshold of UKP30,000 per QALY, CRT-P is cost-effective at a WTP threshold of UKP20,000 per QALY. When the cost and effectiveness of all three treatment strategies are compared with each other, the estimated net benefit from CRT-D is less than with the other two strategies, until the WTP threshold exceeds UKP40,160/QALY.

Authors' methods: Review

Project Status: Completed

URL for project: http://www.hta.ac.uk/1518

Year Published: 2007

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: England, United Kingdom

Organisation Name: NIHR Health Technology Assessment programme

Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK

Contact Name: journals.library@nihr.ac.uk

Contact Email: journals.library@nihr.ac.uk

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