A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial

Marson AG, Appleton R, Baker GA, Chadwick DW, Doughty J, Eaton B, et al
Record ID 32007000537
English
Authors' objectives:

"The aims of the study were to compare clinicians' choice of one of the standard drug treatments (carbamazepine or valproate) versus appropriate comparator new drugs in patients who are managed with single drug treatment and to examine outcomes of treatment with regard to seizure recurrence, QoL impairments, chronic epilepsy and the cost-effectiveness of medical management strategies."

(from executive summary)

Authors' recommendations: Implications for healthcare The study provides evidence that LTG may be a clinical and cost-effective alternative to the existing standard drug treatment, CBZ. Some 88% of patients in Arm A were diagnosed as having partial seizures, so conclusions are applicable to patients with these epilepsy syndromes. For patients in Arm B with idiopathic generalised epilepsy or difficult to classify epilepsy, VPS remains the clinically most effective drug, although TPM may be a cost-effective alternative for some patients. It should be noted that the SANAD trial was not designed to address the issue of safety during pregnancy, an important factor for choice of antiepileptic drugs in women during their childbearing years.
Authors' methods: Review
Details
Project Status: Completed
URL for project: http://www.hta.ac.uk/1031
Year Published: 2007
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Epilepsy
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: 2009 Queen's Printer and Controller of HMSO
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