Authors' objectives:

This guidance aims to assess the current evidence on the use of tissue-cultured limbal stem cell allograft transplantation for regrowth of corneal epithelium.

Authors' recommendations: 1 Guidance 1.1 Current evidence on the safety and efficacy of tissue-cultured limbal stem cell allograft transplantation for regrowth of corneal epithelium does not appear adequate for this procedure to be used without special arrangements for consent and for audit or research. 1.2 Clinicians wishing to use tissue-cultured limbal stem cell allograft transplantation for regrowth of corneal epithelium should take the following actions. : Inform the clinical governance leads in their Trusts. : Ensure that patients understand the uncertainty about the procedure's safety and efficacy, and provide them with clear written information. In addition, use of the Institute's information for patients ('Understanding NICE guidance') is recommended (available from www.nice.org.uk/IPG216publicinfo). : Audit and review clinical outcomes of all patients having tissue-cultured limbal stem cell allograft transplantation for regrowth of corneal epithelium. 1.3 Further research on long-term outcomes and the risks and benefits of long-term systemic immunosuppressant regimes would be useful. The Institute may review the procedure upon publication of further evidence.

Authors' methods: Overview

Project Status: Completed

URL for project: http://www.nice.org.uk/guidance/IPG216

Year Published: 2007

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: England

Organisation Name: National Institute for Health and Care Excellence

Contact Address: Level 1A, City Tower, Piccadilly Plaza, Manchester, M1 4BT

Contact Name: nice@nice.nhs.uk

Contact Email: nice@nice.nhs.uk

Copyright: National Institute for Health and Clinical Excellence (NICE)