[Skin substitutes in burn care]

Department of Science and Technology - Brazilian Health Technology Assessment General Coordination
Record ID 32006001467
Authors' objectives:

To evaluate and compare the effectiveness and safety of different skin substitutes in patients suffering from skin burns, irrespective of degree and extension of the injury, age, gender and ethnic group.

Authors' recommendations: Available evidence is not enough to support the new strategies based on tissue engineering. It is advisable to remain with traditional approaches, mainly autografts for burnsrequiring excision and grafting, allografts for unavailability of donor sites, and finally, topical antibiotics for superficial lesions of partial thickeness, the newest strategies being reserved for research purposes. Further randomized controlled trials with statistical power are necessary to solve the high methodological and clinical heterogeneity inherent to the theme. However, it is fundamental that professionals worldwide try to reach a consensus, lacking thus far, on the kind of manufacture, methods, clinical particularities and relevantoutcomes measures, by means of a multidisciplinary and multicentric effort at all levels.
Project Status: Completed
Year Published: 2005
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Brazil
MeSH Terms
  • Biological Dressings
  • Skin Transplantation
  • Skin, Artificial
  • Tissue Engineering
  • Wound Healing
  • Burns
  • Skin
Organisation Name: Coordenação-Geral de Fomento à Pesquisa e Avaliação de Tecnologias em Saúde, Departamento de Ciência e Tecnologia
Contact Address: Ministerio da Saude, Secretaria de Ciencia, Tecnologia e Insumos Estrategicos, Departamento de Ciencia e Tecnologia, Esplanada dos Ministerios, Edificio sede; bl "G" - 8 andar - SL 834, CEP: 70058-900, Brasilia, DF Brazil, Tel: +55 61 3315 3197 Fax: +55 61 3315 3850
Contact Name: suzanne.jacob@saude.gov.br
Contact Email: suzanne.jacob@saude.gov.br
Copyright: Department of Science and Technology - Brazilian Health Technology Assessment General Coordination (DECIT-CGATS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.