[Drotrecogin alfa in the treatment of severe sepsis]

Department of Science and Technology - Brazilian Health Technology Assessment General Coordination
Record ID 32006001459
Portuguese
Authors' objectives:

To evaluate effectiveness and safety of activated protein C or drotrecogin-alpha in patients with severe sepsis.

Authors' recomendations: Drotrecogin-alpha reduces the risk of mortality in patients with severe sepsis and initially with high risk of mortality, but is not effective in patients at low risk of mortality with severe sepsis. The possibility of type I error (by chance) should not be discarded. On the other hand, drotrecoginalpha for patients with severe sepsis, with or without high risk of mortality, is associated to significant risk of hemorrhagic events.
Details
Project Status: Completed
Year Published: 2005
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Brazil
MeSH Terms
  • Anti-Bacterial Agents
  • Fibrinolytic Agents
  • Protein C
  • Recombinant Proteins
  • Sepsis
Contact
Organisation Name: Coordenação-Geral de Fomento à Pesquisa e Avaliação de Tecnologias em Saúde, Departamento de Ciência e Tecnologia
Contact Address: Ministerio da Saude, Secretaria de Ciencia, Tecnologia e Insumos Estrategicos, Departamento de Ciencia e Tecnologia, Esplanada dos Ministerios, Edificio sede; bl "G" - 8 andar - SL 834, CEP: 70058-900, Brasilia, DF Brazil, Tel: +55 61 3315 3197 Fax: +55 61 3315 3850
Contact Name: suzanne.jacob@saude.gov.br
Contact Email: suzanne.jacob@saude.gov.br
Copyright: Department of Science and Technology - Brazilian Health Technology Assessment General Coordination (DECIT-CGATS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.