[Analysis of factors that can influence the levels of TSH in the neonatal period]

Maceira Rozas MC, Garcia Caeiro AL, Rey Liste MT
Record ID 32006001422
Authors' objectives:

The main objective of this work is to determine the factors that could have an influence on the TSH levels in the neonatal period, either changing the results of the neonatal screening program of the congenital hypothyroidism or independently of its repercussion throughout this one.

Authors' results and conclusions: As a result of the bibliographic search, 55 articles that fulfilled the criteria of selection which had been arranged in advance have been selected. Nine of them analyze the effects of the factors on the results of the screening program. The majority of studies assess the effect of the iodized antiseptics on the thyroid function of the newborn baby and reveal that their use entails an iodine overload that has the resulting risk of a transitory hypothyroidism at a critical age for the child's psychomotor development. Other factors that have been analyzed were the treatment of the mother with amiodarone, the mother's diseases, the perchlorate in the drinking water, the execution of a cardiopulmonary bypass on a newborn baby, etc.
Authors' recommendations: The only factor that has demonstrated an effect on the results of the screening test is the use of iodized antiseptics in the perinatal period. The exposure to the iodized antiseptics is a frequent cause of transitory hyperthyrotropinemia and transitory congenital hypothyroidism. The severity of the thyroid dysfunction is higher in those children that have a low gestational age and/or a low birthweight. In the articles that are included in this systematic review, the factors that have demonstrated an effect on the TSH levels and/or on the thyroid hormones but not on the screening test are the amiodarone, the cardiopulmonary bypass, the Down syndrome and some mother's diseases. There are some discrepancies about the impact that the geographical area of analysis could have on the influence of those factors, as regards the iodine content.
Authors' methods: Systematic review
Project Status: Completed
Year Published: 2006
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Infant, Newborn
  • Thyrotropin
Organisation Name: Scientific Advice Unit, avalia-t; The Galician Health Knowledge Agency (ACIS)
Contact Address: Conselleria de Sanidade, Xunta de Galicia, San Lazaro s/n 15781 Santiago de Compostela, Spain. Tel: 34 981 541831; Fax: 34 981 542854;
Contact Name: avalia-t@sergas.es
Contact Email: avalia-t@sergas.es
Copyright: Galician Agency for Health Technology Assessment (AVALIA-T)
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