Authors' results and conclusions: There are a number of good quality studies included in this summary which described the use of bone marrow cells for autologous transplantation for patients who have experienced a myocardial infarction. Significant improvements were reported by some studies in surrogate outcomes, such as left ventricular ejection fraction, at short-term follow-up. These results were conflicted by another study which reported no significant improvement. Long-term follow-up may indicate that no benefit is afforded to patients who have undergone bone marrow transplant. Most authors agree that more work needs to be undertaken to ascertain the optimal cell type to be used for transplantation, how many cells to use and the timing of cell transfer. In addition studies need to present long-term follow-up data.

Authors' recommendations: Despite the lack of long-term follow-up data, HealthPACT are of the opinion that this technology is likely to enter the Australian health system soon and therefore recommended a horizon scanning report.

Project Status: Completed

Year Published: 2006

URL for published report: Not Available

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Australia

Organisation Name: Adelaide Health Technology Assessment

Contact Address: School of Public Health, Mail Drop 545, University of Adelaide, Adelaide SA 5005, AUSTRALIA, Tel: +61 8 8313 4617

Contact Name: ahta@adelaide.edu.au

Contact Email: ahta@adelaide.edu.au

Copyright: Adelaide Health Technology Assessment (AHTA)