FibroTest-ActiTest for diagnosis and monitoring of fibrosis in chronic liver conditions - horizon scanning review
NHSC
Record ID 32005001229
English
Authors' objectives:
This study aims to summarise the currently available evidence on FibroTest-ActiTest (FT/AT) for diagnosis and monitoring of fibrosis in chronic liver conditions.
Authors' recommendations:
FibroTest-ActiTest (FT/AT) is a non-invasive alternative to liver biopsy which has been clinically validated for patients with chronic hepatitis (B and C), alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). It uses an algorithm to combine the results of serum tests of alpha2-macroglobulin, haptoglobin, apolipoprotien A1, total bilirubin, gamma glutamyltranspeptidase (GGT) and alanine aminotransferase (ALT) to assess the level of fibrosis and necro-inflammatory activity. There are several cross-sectional, retrospective and prospective studies assessing the accuracy of FT/AT compared to liver biopsy. Trial results support FT/AT as an alternative or complement to liver biopsy.
Authors' methods:
Overview
Details
Project Status:
Completed
Year Published:
2005
URL for published report:
http://www.hsric.nihr.ac.uk/search
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Diagnostic Techniques and Procedures
- Fatty Liver
- Hepatitis B
- Hepatitis C
- Liver Diseases, Alcoholic
- Fibrosis
Contact
Organisation Name:
NIHR Horizon Scanning Centre
Contact Address:
The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health and Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom. Tel: +44 121 414 7831, Fax: +44 121 2269
Contact Name:
c.packer@bham.ac.uk
Contact Email:
c.packer@bham.ac.uk
Copyright:
National Horizon Scanning Centre (NHSC)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.