Transfusion and alternative treatment in acute haemorrhage

The Norwegian Knowledge Centre for the Health Services
Record ID 32005001125
Authors' objectives:

The purpose of this review was to assess the evidence base for transfusion versus alternative treatment in acute haemorrhage, defined as treatment instituted within 24 hours after the start of the acute haemorrhage. The report concerns the effect of treatment in volume replacement, oxygen delivery to prevent tissue hypoxia and haemostasis to stop or reduce bleeding by drugs and other methods. The review team was also asked to give an overview of side effects associated with transfusion in addition to legal and ethical conciderations related to haemotherapy.

Authors' recomendations: With the exception of fibrinolytic drugs that reduce the need for transfusion there is generally a weak evidence base for haemotherapy. It is especially weak for the transfusion of erythrocytes and thrombocytes. There are several uncertainties about the quality of transfusion products stored in blood banks. No study results indicate that practice in Norway involves too high consumption of blood and blood products. The increasing mean age of the population and the increasing number of new therapeutic possibilities may indicate that the need for bloodproducts will remain stable over time. It is considered a high priority for the Norwegian and inter national field of transfusion medicine to improve the evidencebase for haemotherapy.
Authors' methods: Systematic review
Project Status: Completed
URL for project:
Year Published: 2005
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Norway
MeSH Terms
  • Blood Transfusion
  • Hemorrhage
Organisation Name: Norwegian Institute of Public Health
Contact Address: Universitetsgata 2, Postbox 7004 St. Olavs plass, NO-0310 Oslo NORWAY. Tel: +47 23 25 50 00; Fax: +47 23 25 50 10;
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Copyright: The Norwegian Knowledge Centre for the Health Services
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