[Effectiveness and safety of the autologous chondrocyte implant]

Ruano-Ravina A, Jato M
Record ID 32005000465
Spanish
Authors' objectives:

Chondral lesions on the knee are a problem with a complicated solution due to the low capability of repair of the hyaline cartilague. There are various surgical treatments, and amongst them the autologous chondrocyte implant (ACI).The aim of this review was to assess the efficacy, effectiveness and safety of the ACI.

Authors' results and conclusions: The type of papers retrieved was very heterogeneous. 4 systematic reviews and 3 clinical trials were found. The other studies were case series. Clinical trials showed no difference between ACI and microfracturing or transplantation of osteochondral plugs. A very slight difference favouring mosaicplasty vs ACI was found in the other clinical trial. Case series offer an improvement in the knee condition in patients treated with ACI. Respect to safety, ACI seem to be, in general, a safe procedure.
Authors' recommendations: There is no evidence showing that ACI is better than other procedures on the treatment of chondral lesions of the knee. With the available information, ACI is a safe procedure.
Authors' methods: Systematic Review
Details
Project Status: Completed
URL for project: http://www.sergas.es/MostrarContidos_N3_T02.aspx?IdPaxina=60056&uri=http://www.sergas.es/gal/Servicios/docs/AvaliacionTecnoloxias/CondrocitosINF2005_01.pdf&hifr=750&seccion=0
Year Published: 2005
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Safety
  • Chondrocytes
  • Transplantation, Autologous
Contact
Organisation Name: Scientific Advice Unit, avalia-t; The Galician Health Knowledge Agency (ACIS)
Contact Address: Conselleria de Sanidade, Xunta de Galicia, San Lazaro s/n 15781 Santiago de Compostela, Spain. Tel: 34 981 541831; Fax: 34 981 542854;
Contact Name: avalia-t@sergas.es
Contact Email: avalia-t@sergas.es
Copyright: Galician Agency for Health Technology Assessment (AVALIA-T)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.