CEA-Scan (R) for imaging recurrence and/or metastases in patients with histologically demonstrated carcinoma of the colon or rectum
Medical Services Advisory Committee
Record ID 32005000415
English
Authors' objectives:
This report evaluates the safety and effectiveness of CEA-Scan (R) (a functional imaging technique for the detection of recurrent colorectal cancer) for imaging recurrence and/or metastases in patients with histologically demonstrated carcinoma of the colon or rectum.
Authors' recommendations:
CEA-Scan (R) may generally be considered to be safe for administration as a single dose. However, patients receiving murine antibodies should be monitored for acute sensitivity reactions during and immediately after infusion with CEA-Scan. There is an increased risk of adverse reaction with repeated dosage and the long-term safety of CEA-Scan requires further study. A precise estimate of the accuracy of CEA-Scan was hampered by the heterogeneity of the reported clinical results of the test and by methodological weaknesses in the reported studies. Nevertheless, the overall diagnostic accuracy of CEA-Scan when analysed by patient was generally low. When the accuracy of CEA-Scan was assessed by disease site and lesions, CEA-Scan more accurately identified local recurrence and extra hepatic disease than liver metastases. The ability of CEA-Scan to correctly identify patients with liver disease, which is the most common site of recurrence, was poor. When CEA-Scan was compared to FDG-PET in two head-to-head studies, it was generally less accurate than FDG-PET for the diagnosis of recurrent colorectal cancer. However, not all patients benefit from FDG-PET and CEA-Scan may be useful in selected patients.
Authors' methods:
Review
Details
Project Status:
Completed
URL for project:
http://www.msac.gov.au/reports.htm
Year Published:
2004
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Australia
MeSH Terms
- Costs and Cost Analysis
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Colonic Neoplasms
- Rectal Neoplasms
Contact
Organisation Name:
Medical Services Advisory Committee
Contact Address:
MSAC (MDP 107), GPO Box 9848, Canberra, ACT 2601, Australia. Tel: +61 2 6289 6811; Fax: +61 2 6289 8799.
Contact Name:
msac.secretariat@health.gov.au
Contact Email:
msac.secretariat@health.gov.au
Copyright:
Medical Services Advisory Committee (MSAC)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.