Authors' objectives: To provide an appraisal of the status of quantitative ultrasound (QUS) for bone density measurement, considering its performance and predictive value compared to x-ray based technology (DXA) and issues related to its use in Canada.

Authors' results and conclusions: Data could be identified for five machines which are possibly relevant to the Canadian market. Comparative data on these devices are limited, though all appear to have about the same level of precision. There are no data available on accuracy. There is good correlation of QUS parameters with fracture prevalence for study populations. Values for relative risk are similar to, though somewhat lower than, corresponding data for DXA measurement. QUS measurements show only moderate correlation with those from DXA. There is no evidence of increased capture of an at-risk population if both tests are performed. There is little information on the use of QUS outside the research setting. Measures of its performance and guidelines for use in routine clinical practice are not yet available. Use of QUS as a pre-screening tool prior to DXA appears inappropriate. QUS may provide an option for use in under-serviced populations as an alternative to DXA. If such an approach were adopted, a number of practical issues would need consideration, including the need for confirmatory tests and potential duplication of services.

Authors' recommendations: Quantitative calcaneal ultrasound appears to be a promising diagnostic technology but its role in diagnosis of osteoporosis remains unclear. Further evidence regarding its long-term precision, predictive ability and potential cost-effectiveness is required before its place in routine health care services can be established.

Authors' methods: Systematic review

Project Status: Completed

Year Published: 1998

URL for published report: http://www.ihe.ca/advanced-search/quantitative-ultrasound-for-bone-density-measurement

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Institute of Health Economics

Contact Address: 1200, 10405 Jasper Avenue, Edmonton, Alberta, Canada, T5J 3N4. Tel: +1 780 448 4881; Fax: +1 780 448 0018;

Contact Name: djuzwishin@ihe.ca

Contact Email: djuzwishin@ihe.ca

Copyright: <p>Alberta Heritage Foundation for Medical Research</p>