Osteogenic protein-1 for long bone nonunion: an evidence-based analysis

Record ID 32005000349
Authors' objectives:

The Ontario Health Technology Advisory Committee (OHTAC) asked the Medical Advisory Secretariat to conduct a health technology assessment on osteogenic protein-1 (OP-1) for long bone nonunion.

Authors' recommendations: Based on level 1 evidence (1 randomized controlled trial), OP-1 is a reasonable alternative to autologous bone grafting in the treatment of long bone nonunions. Based on level 4 evidence (10 studies, a total of 301 patients), percutaneous autologous bone marrow grafting is effective in the treatment of long bone nonunions in patients with no active infection at the fracture site. Based on the above evidence and the fact that both procedures (percutaneous autologous bone marrow grafting and OP-1) eliminate the risk of donor site morbidity and reduce the risk of infection at the recipient site, the following questions should be considered in making decisions regarding these competing technologies : - Should the effectiveness of percutaneous bone marrow grafting as a treatment modality for non-infected long bone nonunions be explored further? - Should access to OP-1 be provided to the patients with long bone nonunions (according to the definitions set by FDA) when other methods of treatment have failed?
Authors' methods: Systematic review
Project Status: Completed
Year Published: 2005
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Bone Morphogenetic Proteins
  • Bone Transplantation
  • Costs and Cost Analysis
  • Fractures, Bone
  • Fractures, Ununited
Organisation Name: Medical Advisory Secretariat
Contact Address: Medical Advisory Secretariat, 20 Dundas Street West, 10th Floor, Toronto, ON M5G 2N6 CANADA. Tel: 416-314-1092l; Fax: 416-325-2364;
Contact Name: MASinfo.moh@ontario.ca
Contact Email: MASinfo.moh@ontario.ca
Copyright: Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.