Authors' objectives:

This study aims to assess the current evidence on the safety and efficacy of selective internal radiation therapy for colorectal metastases in the liver.

Authors' recommendations: Guidance 1.1 Current evidence on the safety of selective internal radiation therapy (SIRT) for colorectal metastases in the liver appears adequate. With regard to efficacy, the procedure may reduce tumour bulk, but there is a lack of evidence of symptom relief or increased survival, and combination with other treatments makes interpretation of the published literature difficult. 1.2 Clinicians wishing to undertake selective internal radiation therapy for colorectal metastases in the liver should take the following actions. - Ensure that patients understand the uncertainty about the procedures safety and efficacy and provide them with clear written information. Use of the Institute's Information for the Public is recommended. - Audit and review clinical outcomes of all patients having selective internal radiation therapy for colorectal metastases in the liver. 1.3 Publication of research studies with outcome measures which include survival will be useful in reducing the current uncertainty about the efficacy of the procedure. The Institute may review the procedure upon publication of further evidence.

Authors' methods: Overview

Project Status: Completed

URL for project: http://www.nice.org.uk/cms/ip/ipcat.aspx?c=80295

Year Published: 2004

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: England, United Kingdom

Organisation Name: National Institute for Clinical Excellence

Contact Address: MidCity Place, 71 High Holborn, London WC1V 6NA, UK. Tel: +44 020 7067 5800; Fax: +44 020 7067 5801

Contact Name: nice@nice.nhs.uk

Contact Email: nice@nice.nhs.uk

Copyright: National Institute for Clinical Excellence (NICE)