Bone marrow transplantation using mismatched related and matched unrelated donors: Consideration of eligibility for national funded centre status

Australian Institute of Health and Welfare
Record ID 31995000066
Authors' objectives:

To determine whether mismatched related donor (MMRD) and matched unrelated donor (MUD) bone marrow transplantation (BMT) should be funded at a limited number of centres under a national program.

Authors' results and conclusions: National caseload is 25 to 60 MMRD BMTs and 100 to 200 MUD BMTs annually. Despite high mortality and morbidity rates, MUD BMT offers the possibility of a longer life to patients with terminal disease. The technology is evolving, and in the future better outcomes might be possible. MMRD BMT is adjunctive to matched related donor BMT.
Authors' recommendations: MMRD and MUD BMT should not be limited to one or two centres in Australia. Inequalities in reimbursement of fees for donor searches needs consideration, where successful searches are able to be reimbursed from discretionary funds but unsuccessful searches are not. MUD BMT is a new technology with limited data available about outcomes and effectiveness relative to alternatives. To ensure the provision of high quality services, the Australian Bone Marrow Transplantation Co-operative Study Group should formally determine minimum standards for MUD BMT, and centres performing such transplants should meet these standards. A national database should be established to provide information for research and for quality assurance. National protocols and guidelines would need to be developed for this. Standard policies should be implemented in and national linkages established between tissue typing laboratories, to assist in research.
Project Status: Completed
URL for project:
Year Published: 1992
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Australia
MeSH Terms
  • Bone Marrow Transplantation
Organisation Name: Australian Health Technology Advisory Committee
Contact Address: Naarilla Hirsch, Australian Institute of Health and Welfare Health Technology Unit, GPO Box 570, Canberra, ACT, 2601, Australia
Copyright: Australian Institute of Health and Welfare
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.