Clopidogrel in the treatment of non-ST-segment-elevation acute coronary syndrome

National Institute for Clinical Excellence
Record ID 32004000671
English
Authors' objectives:

To provide guidance on the use of clopidogrel in the treatment of non-ST-segment-elevation acute coronary syndrome.

Authors' recommendations: 1.1 Clopidogrel, in combination with low-dose aspirin, is recommended for use in the management of non-ST-segment-elevation acute coronary syndrome (ACS) in people who are at moderate to high risk of myocardial infarction (MI) or death. 1.2 For the purposes of this guidance, moderate to high risk of MI or death in people presenting with non-ST-segment-elevation ACS can be determined by clinical signs and symptoms, accompanied by one or both of the following: the results of clinical investigations, such as new ECG changes (other than persistent ST-segment-elevation), indicating ongoing myocardial ischaemia, particularly dynamic or unstable patterns the presence of raised blood levels of markers of cardiac cell damage such as troponin. 1.3 It is recommended that treatment with clopidogrel in combination with low-dose aspirin should be continued for up to 12 months after the most recent acute episode of non-ST-segment-elevation ACS (as defined in Sections 1.1 and 1.2). Thereafter, standard care, including treatment with low-dose aspirin alone, is recommended.
Authors' methods: Systematic review
Details
Project Status: Completed
URL for project: http://www.nice.org.uk/page.aspx?o=213432
Year Published: 2004
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Platelet Aggregation Inhibitors
  • Angina, Unstable
  • Coronary Disease
  • Myocardial Infarction
Contact
Organisation Name: National Institute for Clinical Excellence
Contact Address: MidCity Place, 71 High Holborn, London WC1V 6NA, UK. Tel: +44 020 7067 5800; Fax: +44 020 7067 5801
Contact Name: nice@nice.nhs.uk
Contact Email: nice@nice.nhs.uk
Copyright: National Institute for Clinical Excellence (NICE)
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