Original Title: Biomarqueurs tumoraux liés à la prise en charge des personnes atteintes de tumeurs neuroendocrines de stades avancé

Authors' objectives: With the aim of promoting the judicious use of this type of analysis and to standardize patient care, INESSS has been mandated by the Direction de la cancérologie (DC) to compile a list of useful biomarkers to guide the management of people with various types of solid tumors, including advanced neuroendocrine tumors (NET).

Authors' results and conclusions: RESULTS: A total of 20 publications were selected regarding tumor biomarkers recommended for the management of advanced NET or solid tumors aimed by agnostic therapy (indirectly including NET). The biomarkers recommended in the selected publications are predictive and include various types of alterations in the BRAF genes (mainly V600E mutations), the VHL gene, fusions involving the RET and NTRK genes, high microsatellite instability (MSI-H), mismatch repair defects (dMMR), and high tumor mutational burden (TMB-H). The ability of these genes to predict treatment response is based on cohorts of various solid tumors, including a very limited number of NETs. In addition to their ability to predict treatment response, some of these biomarkers, as well as Ki-67, also have prognostic and/or diagnostic value, according to some organizations. CONCLUSION: According to the experts consulted, information provided by biomarker testing would be useful for the management of people with advanced NET, as it contributes to a better characterization of the disease and enables a certain number of individuals to benefit from it.

Authors' methods: An exhaustive literature review (practice guidelines and expert consensus) was conducted to identify tumor biomarkers recommended for the management of advanced NET or solid tumors targeted by an agnostic therapeutic approach (indirectly including NET).

Project Status: Completed

Year Published: 2026

URL for published report: https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/Oncologie/Biomarqueurs_neuroendocrines_EC_INESSS.pdf

English language abstract: An English language summary is available

Publication Type: Other

Country: Canada

Province: Quebec

Organisation Name: Institut national d'excellence en sante et en services sociaux

Contact Address: L'Institut national d'excellence en sante et en services sociaux (INESSS) , 2021, avenue Union, bureau 10.083, Montreal, Quebec, Canada, H3A 2S9;Tel: 1+514-873-2563, Fax: 1+514-873-1369

Contact Name: demande@inesss.qc.ca

Contact Email: demande@inesss.qc.ca

Copyright: L'Institut national d'excellence en sante et en services sociaux (INESSS)