Effectiveness of non-pharmacological interventions for fatigue in adults with long-term conditions: a synopsis of the EIFFEL mixed-methods evidence synthesis

Leaviss J, Booth A, Coyle D, Daly G, Davis S, Dawes H, Deary V, Dwivedi K, Forsyth JE, Fryer K, McCormick S, Martyn-St James M, Newton J, Ren S, Rooney G, Sutton A, Mon-Yee M, Burton C
Record ID 32018015736
English
Authors' objectives: Fatigue is common in many long-term medical conditions. Interventions to date have largely been in single conditions. To conduct a mixed-methods evidence synthesis of the clinical and cost-effectiveness and acceptability of non-pharmacological interventions for fatigue in adults with long-term medical conditions.
Authors' results and conclusions: Included studies The clinical effectiveness review included 88 randomised controlled trials, involving 27 interventions, with 6636 participants included at end of treatment, 1849 in the short term and 2322 in the long term.
Authors' methods: Eligibility criteria Randomised controlled trials, cost-effectiveness studies, or qualitative studies of non-pharmacological interventions for fatigue in long-term medical conditions where fatigue was either a criterion for inclusion, the primary target of the intervention, or the primary or coprimary outcome. Studies of post-infectious, post-traumatic, cancer-related or idiopathic fatigue were excluded.
Details
Project Status: Completed
URL for project: https://www.journalslibrary.nihr.ac.uk/programmes/hta/NIHR154660
Year Published: 2026
URL for published report: https://www.journalslibrary.nihr.ac.uk/hta/GJCB1006
URL for additional information: English
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: England, United Kingdom
DOI: 10.3310/GJCB1006
MeSH Terms
  • Fatigue
  • Adult
  • Chronic Disease
  • Exercise
  • Exercise Therapy
  • Cognitive Behavioral Therapy
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.