[Evaluation of injectable type I collagen in AMIC/ACIC arthroscopic applications]

Pedrosa-Pérez L, Rodríguez-Rojas L, del Pino-Sedeño T, Romero-Khoury C, Carmona-Rodríguez M
Record ID 32018015640
Spanish
Original Title: Evaluación del colágeno tipo I inyectable empleado en el contexto de la técnica AMIC/ACIC realizada por artroscopia
Authors' objectives: To evaluate the effectiveness and safety of injectable type I collagen used in AMIC/ACIC arthroscopic procedures, as well as its economic, ethical, legal, organizational, social, and environmental implications.
Authors' results and conclusions: Conclusions • The evidence is very uncertain regarding the efficacy and safety of injectable type I collagen compared with standard techniques for the treatment of articular cartilage lesions. • The cost-effectiveness of using injectable type I collagen compared with the current technologies of choice for these indications is unknown.
Authors' methods: A systematic review of the scientific literature was conducted to assess the effectiveness, safety, and cost-efficiency of this technology. Study inclusion followed the PICO criteria: - Population: Adults (individuals over 18 years old) with chondral lesions eligible for AMIC/ACIC treatment - Intervention: Injectable type I collagen used in the context of AMIC/ACIC arthroscopy - Comparator: AMIC/ACIC using other devices - Outcomes: Change in symptom intensity at short, medium, and long term, measured using specific scales (such as variations in pain intensity or morphological changes in the lesion); changes in quality of life; need for revision surgery; conversion to total joint arthroplasty; adverse events or complications; and outcomes related to economic, ethical, legal, organizational, social, and environmental aspects. Risk of bias and quality of evidence were assessed using the RoB 2, MINORS and EPOC tools. A qualitative synthesis of the results was performed.
Details
Project Status: Completed
Year Published: 2026
URL for published report: https://hdl.handle.net/20.500.12105/27353
URL for additional information: https://redets.sanidad.gob.es/productos/buscarProductos.do?metodo=detalle&id=1365
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Chondrocytes
  • Cartilage, Articular
  • Collagen Type I
  • Arthroscopy
  • Osteoarthritis, Hip
  • Osteoarthritis, Knee
  • Injections, Intra-Articular
Keywords
  • Chondrogenesis
  • Cartilage Diseases
  • Injectable type I collagen
  • ChondroFiller
  • autologous matrix-induced chondrogenesis
  • autologus collagen-induced chondrogenesis
Contact
Organisation Name: Agencia de Evaluacion de Tecnologias Sanitarias
Contact Address: Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;
Contact Name: Esther E. García Carpintero
Contact Email: eegarcia@isciii.es
Copyright: Agencia de Evaluacion de Tecnologias Sanitarias
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.