Original Title: Efectividad de la tomografía de impedancia eléctrica en el manejo de pacientes críticos con síndrome de distrés respiratorio agudo, en tratamiento con ventilación mecánica

Authors' objectives: The primary objective of this report is to evaluate the effectiveness of pulmonary EIT in the management of critically ill patients with ARDS on mechanical ventilation. The secondary objectives of this report are: To identify the safety profile of EIT and to assess possible considerations relevant to the organisational and implementation aspects of using this intervention. To assess the economic impact of EIT in critically ill patients with ARDS on mechanical ventilation.

Authors' results and conclusions: Conclusions Although evidence is still scarce, the reviewed studies show that EIT technology could be an option for PEEP monitoring and titration in critically ill patients with ARDS and mechanical ventilation, and that it may contribute to reducing the occurrence of VILI in this type of clinical situation. The main limitations found in the included clinical trials were related o possible bias in the selection of the reported results. In the observational study, the main limitations were confounding factors and potential bias in the selection of participants. In the selected studies, the technology evaluated showed statistically significant differences against the results of the comparator group for the mortality variable. No evidence on the occurrence of adverse events associated with its implementation was found in the studies included in this report. No studies on the cost-effectiveness of this intervention have been identified. More research is needed to expand the available evidence and its methodological quality, as well as studies that include economic and organisational aspects related to the implementation of the technology. For future lines of SR development and health technology assessment reports, it is advisable to determine precisely the comparator to be considered in the research question and to include other populations likely to benefit from EIT monitoring.

Authors' methods: We conducted a systematic review (SR) of the available scientific literature on the effectiveness of EIT for monitoring critically ill patients with ARDS on mechanical ventilation between 1 January 2010 and 1 October 2023. Study quality was assessed using the ROB-II and ROBINS-I tools, depending on the study design. Quantitative synthesis of results was performed whenever possible. In addition, an RS was carried out in specific databases to evaluate the available scientific literature on economic evaluations of this technology.

Project Status: Completed

Year Published: 2025

URL for published report: https://hdl.handle.net/20.500.12105/26594

URL for additional information: https://redets.sanidad.gob.es/productos/buscarProductos.do?metodo=detalle&id=1285

English language abstract: An English language summary is available

Publication Type: Full HTA

Country: Spain

Organisation Name: Agencia de Evaluacion de Tecnologias Sanitarias

Contact Address: Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;

Contact Name: Esther E. García Carpintero

Contact Email: eegarcia@isciii.es

Copyright: Agencia de Evaluacion de Tecnologias Sanitarias