[Diagnostic effectiveness of rapid immunochromatographic tests for the detection of Campylobacter spp. and Salmonella spp. in patients with acute gastroenteritis]

Rodríguez Ortiz de Salazar B, García Carpintero EE, Rodríguez Rojas L, Cárdaba Arranz M
Record ID 32018015634
Spanish
Original Title: Efectividad diagnóstica de las pruebas inmunocromatográficas para la detección rápida de Campylobacter spp. y Salmonella spp. en pacientes con gastroenteritis aguda
Authors' objectives: The main objective is to evaluate the effectiveness and safety of immunochromatographic tests for detection of Campylobacter spp. and Salmonella spp. in stool samples from patients with acute gastroenteritis. The specific objectives are to determine the diagnostic performance of the IC tests for detection of Campylobacter spp. and Salmonella spp. in in comparison with the reference tests, and to assess the economic impact of IC compared to the reference tests.
Authors' results and conclusions: Conclusions The analysed studies reveal what immunochromatographic technology shows a high sensitivity and specificity in the detection of Campylobacter spp. and moderate sensitivity and high specificity in the detection of Salmonella spp. in stool samples from patients with acute gastroenteritis. Studies assessing the diagnostic performance of these tests as point of care tests were not found. Similarly, analysing the diagnostic performance based on the patient population (paediatrics or adults) was not possible. Further research is needed to evaluate the effectiveness, implementation issues, and efficiency of these tests in comparison to standard practice.
Authors' methods: A systematic review of studies on the effectiveness and safety of IC in the detection of Campylobacter spp and Salmonella spp. in stool samples from patients with acute gastroenteritis has been carried out. The index tests were IC tests. Stool culture, PCR and EIA , or a combination of the last two techniques, have been used as reference tests. Original randomized and non-randomized articles were included. The methodological quality of the included studies and the risk of bias was assessed with the QUADAS-2 tool for the quality assessment of diagnostic accuracy studies. The performance measures used were sensitivity and specificity. Quantitative analyses or meta-analysis was performed for variables in which statistical combination of data was possible.
Details
Project Status: Completed
Year Published: 2025
URL for published report: https://hdl.handle.net/20.500.12105/26939
URL for additional information: https://redets.sanidad.gob.es/productos/buscarProductos.do?metodo=detalle&id=1338
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Spain
MeSH Terms
  • Gastroenteritis
  • Campylobacter Infections
  • Salmonella Infections
  • Campylobacter coli
  • Reagent Kits, Diagnostic
  • Bacteriological Techniques
  • Chromatography
  • Rapid Diagnostic Tests
Keywords
  • Rapid test/quick test
  • antigen test
  • Diagnosis test
  • Gastrointestinal acute infection
  • immunochromatographic test
Contact
Organisation Name: Agencia de Evaluacion de Tecnologias Sanitarias
Contact Address: Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;
Contact Name: Esther E. García Carpintero
Contact Email: eegarcia@isciii.es
Copyright: Agencia de Evaluacion de Tecnologias Sanitarias
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