Original Title: Uso de rellenadores dérmicos de ácido hialurónico para el tratamiento de patología periocular asociada a parálisis facial y a otras causas de malposición palpebral

Authors' objectives: To evaluate the efficacy and safety of the injection of dermal fillers with HA in the periocular area, in the treatment of palpebral alterations and malpositions due to facial paralysis or other causes, as an alternative to surgery in patients who are refractory or not eligible to conventional surgical treatment.

Authors' results and conclusions: Conclusions The scientific evidence available on the use of HA fillers for the treatment of periocular pathologies caused by facial paralysis or other etiologies is scarce and of low quality, being mainly constituted by case series, with pre-post measurement of results, without comparators and, in most cases, with retrospective data collection. The selected studies presented heterogeneity in the use of the intervention, in the measurement instruments and in the follow-up times. The sample size of the studies was small. The information available in the studies included in this review, as well as previous evidence from studies in which this intervention has been used for aesthetic purposes, suggests that overall the intervention it is safe, with non-serious, local ized and time-limited adverse effects. Consequently, the available evidence on the efficacy and safety of HA fillers for the treatment of periocular pathologies caused by facial paralysis or other etiologies is insufficient.

Authors' methods: A systematic review (SR) of the literature available until November 2021 was performed for studies on the efficacy and safety of interventions with HA fillers in patients with lagophthalmos, blepharoptosis, palpebral retraction, entropion and ectropion, of paralytic, iatrogenic, traumatic, cicatricial or involutional origin. The type of studies included were systematic reviews and/or meta-analyses, randomized clinical trials (RCTs) and observational studies. Health technology assessment reports and clinical practice guidelines were searched. For the evaluation of the quality of the studies with a case series design, the Evidence Assessment Scale for case series designed by the Institute of Health Economics (IHE) was used. The risk of bias in the included SR was evaluated with the AMSTAR 2 tool. Data extraction from each study was performed independently by two review ers, discrepancies being resolved by consensus. The data has been synthesized in a descriptive way and the results have been expressed in a narrative way from the evidence tables

Project Status: Completed

Year Published: 2022

URL for published report: http://hdl.handle.net/20.500.12105/18867

URL for additional information: https://redets.sanidad.gob.es/productos/buscarProductos.do?metodo=detalle&id=1198

English language abstract: An English language summary is available

Publication Type: Full HTA

Country: Spain

DOI: 10.4321/repisalud.18867

Organisation Name: Agencia de Evaluacion de Tecnologias Sanitarias

Contact Address: Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;

Contact Name: Esther E. García Carpintero

Contact Email: eegarcia@isciii.es

Copyright: Agencia de Evaluacion de Tecnologias Sanitarias