Original Title: Eficacia y seguridad de la oxigenoterapia hiperbárica en el tratamiento de intoxicación por monóxido de carbono, oclusión de arteria central de la retina, Covid persistente, pérdida de audición súbita o encefalopatía post-anoxémica

Authors' objectives: The objective is to evaluate the efficacy, effectiveness and safety of HBOT in patients with carbon monoxide poisoning, central retinal artery occlusion, Long Covid, sudden hearing loss or post-anoxemic encephalopathy.

Authors' results and conclusions: CONCLUSIONS: Carbon monoxide poisoning • HBOT is less effective than NBOT in improving headache and the incidence of fatigue. • It appears to be superior in some neuropsychological subscales and in global neuropsychological assessment compared to NBOT. Central retinal artery occlusion • HBOT may improve visual acuity compared to NBOT. Long Covid • HBOT is superior to NBOT in improving neurocognitive performance and executive function. • HBOT improves quality of life in the domains of physical limitation and energy compared to NBOT. • HBOT improves depression, its somatization, pain interference and sleep disorders in PSQI global score. Sudden hearing loss (SHL) • The small sample size of the primary studies included in the analysed SR, the heterogeneity in the HBOT regimen applied and the high risk of bias of the primary studies do not allow a robust conclusion on the efficacy and safety of HBOT in the treatment of SHL. Post-anoxemic encephalopathy • The systematic review has not identified any comparative studies that allow conclusions to be drawn on the effectiveness and safety of treatment with HBOT in patients with post-anoxemic encephalopathy. • On the basis of the available evidence, HBOT cannot be considered as a single first-line treatment in the studied conditions. • Robust evidence of the specific efficacy of HBOT on some of these diseases, combined with other treatments through high-quality studies, is needed to be able to clearly conclude that it is an effective co-adjuvant therapy for the assessed conditions.

Authors' methods: A systematic review (SR) of scientific studies evaluating the therapeutic efficacy and effectiveness of HBOT was carried out. A search of clinical guidelines, randomised clinical trials (RCTs), systematic reviews, meta-analyses and evaluation reports was carried out in different databases (Medline, Embase, Cochrane Database, INAHTA Database), in Health Technology Assessment Agencies databases and on clinical trial websites. A manual search was also carried out based on the references of the studies found. Subsequently, a critical reading of the selected literature and an extraction of the most important data, as well as a synthesis of the evidence, was carried out.

Project Status: Completed

Year Published: 2023

URL for published report: https://hdl.handle.net/20.500.12105/25560

URL for additional information: https://redets.sanidad.gob.es/productos/buscarProductos.do?metodo=detalle&id=1248

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Spain

Organisation Name: Agencia de Evaluacion de Tecnologias Sanitarias

Contact Address: Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;

Contact Name: Esther E. García Carpintero

Contact Email: eegarcia@isciii.es

Copyright: Agencia de Evaluacion de Tecnologias Sanitarias